INT306868

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.01
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (E2F1) nucleoplasm (E2F1) mitochondrion (E2F1)
nucleus (E2F1) DNA binding (E2F1) transcription factor binding (E2F1)
Anatomy Link Frequency
H69 4
E2F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 260 99.92 Very High Very High Very High
metalloproteinase 1 44.64 Quite Low
aspirin 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Gabapentin 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 126 98.68 Very High Very High Very High
Repression 4 95.92 Very High Very High Very High
Cancer 142 79.36 Quite High
Apoptosis 18 65.40 Quite High
Body Weight 4 32.12 Quite Low
Targeted Disruption 4 20.04 Low Low
Gastrointestinal Neoplasms 2 11.52 Low Low
Injury 1 8.84 Low Low
Lung Cancer 20 5.00 Very Low Very Low Very Low
Metastasis 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicted that E2F-1 response elements were located in the region between ?
Positive_regulation (elements) of Gene_expression (response) of E2F-1
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Then, we did dose response experiments for E2F-1 overexpression on TSP1 promoter activity.
Positive_regulation (overexpression) of Gene_expression (overexpression) of E2F-1
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.10 Pain Relevance 0
Flag empty vector or different dose of Flag-tagged E2F-1 expression vector, TSP1(?
Positive_regulation (tagged) of Gene_expression (expression) of E2F-1
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.09 Pain Relevance 0
E2F1, E2F2, E2F3, E2F4, E2F5 and E2F6 siRNAs were individually transfected in H69 cells.
Positive_regulation (transfected) of Gene_expression (transfected) of E2F1 in H69
4) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.59 Pain Relevance 0.82
E2F1–6-siRNAs were individually transfected in H69 cells using Oligofectamine reagent.
Positive_regulation (transfected) of Gene_expression (transfected) of E2F1 in H69
5) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.23 Pain Relevance 0.45
Similarly, the E2F1 promoter was found to contain two putative Tcf-binding elements, and promoter activity is inhibited by overexpression of ?
Positive_regulation (overexpression) of Gene_expression (overexpression) of E2F1
6) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0

General Comments

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