INT306869

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.10
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F4) nucleus (E2F4) DNA binding (E2F4)
transcription factor binding (E2F4)
Anatomy Link Frequency
H69 4
E2F4 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 650 97.84 Very High Very High Very High
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 315 90.04 High High
Cancer 210 78.64 Quite High
Apoptosis 30 64.68 Quite High
Body Weight 10 31.40 Quite Low
Lung Cancer 50 5.00 Very Low Very Low Very Low
Reprotox - General 1 20 5.00 Very Low Very Low Very Low
Disease 15 5.00 Very Low Very Low Very Low
Metastasis 10 5.00 Very Low Very Low Very Low
Weight Loss 10 5.00 Very Low Very Low Very Low
Breast Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, no E2F4 or very low levels of E2F4 were bound to these promoters in proliferating H69 cells (Fig. 6, left panel, lane 6 from left).
Gene_expression (levels) of E2F4 in H69
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.09 Pain Relevance 0.44
E2F1, E2F2, E2F3, E2F4, E2F5 and E2F6 siRNAs were individually transfected in H69 cells.
Gene_expression (transfected) of E2F4 in H69
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.58 Pain Relevance 0.82
Western blotting analysis showed that the transfection of either sets of E2F4-siRNAs produced efficient suppression of E2F4 protein levels in H69 cells (Fig. 5, C).


Gene_expression (produced) of E2F4 in H69
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.28 Pain Relevance 0.41
In contrast, no E2F4 or very low levels of E2F4 were bound to these promoters in proliferating H69 cells (Fig. 6, left panel, lane 6 from left).
Gene_expression (levels) of E2F4 in H69
4) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.14 Pain Relevance 0.44
Chemically synthesized, double-stranded siRNA for E2F1, E2F2, E2F3, E2F4, E2F5 and E2F6 was purchased from Santa Cruz Biotechnology.
Gene_expression (synthesized) of E2F4
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0 Pain Relevance 0

General Comments

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