INT306875

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.51
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDC6) nucleoplasm (CDC6) mitosis (CDC6)
nucleus (CDC6) cell division (CDC6) cytoplasm (CDC6)
Anatomy Link Frequency
H69 1
CDC6 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 390 99.54 Very High Very High Very High
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 189 99.12 Very High Very High Very High
Cancer 126 78.60 Quite High
Lung Cancer 30 75.40 Quite High
Metastasis 6 50.24 Quite High
Non-small-cell Lung Cancer 6 45.32 Quite Low
Genomic Instability 3 44.96 Quite Low
Apoptosis 18 5.00 Very Low Very Low Very Low
Reprotox - General 1 12 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Weight Loss 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies revealed that the treatment of human SCLC cells with capsaicin leads to differential recruitment of E2Fs on E2F-responsive promoters like cyclin E, TS, cdc25A and cdc6.
Localization (recruitment) of cdc6 associated with qutenza and small cell lung cancer
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.64 Pain Relevance 0.26
The treatment of H69 human SCLC cells with capsaicin leads to a switch in E2F subtypes on cyclin E, TS, cdc25A and cdc6 promoters; E2F1–3 are dissociated from the promoter, and E2F4 and p130 are recruited.
Localization (recruited) of cdc6 in H69 associated with qutenza and small cell lung cancer
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.72 Pain Relevance 0.40
We selected cyclin E, TS, cdc25A and cdc6.
Localization (selected) of cdc6
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.15 Pain Relevance 0.86

General Comments

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