INT306880

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 6.32
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NOLC1) mitosis (NOLC1) nucleolus (NOLC1)
nucleus (NOLC1) cell cycle (NOLC1) DNA binding (NOLC1)
Anatomy Link Frequency
blood 1
neurons 1
H69 1
astrocytes 1
NOLC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 33 99.54 Very High Very High Very High
qutenza 130 97.32 Very High Very High Very High
Inflammation 13 66.32 Quite High
chemokine 21 56.80 Quite High
Neurobehavioral 21 36.00 Quite Low
Central nervous system 9 6.32 Low Low
glial activation 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 567 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 36 99.00 Very High Very High Very High
Infection 102 98.44 Very High Very High Very High
Small Cell Lung Cancer 63 96.90 Very High Very High Very High
Sprains And Strains 12 91.20 High High
Death 15 85.52 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 219 84.00 Quite High
Apoptosis 12 83.60 Quite High
Hepatitis 3 80.24 Quite High
INFLAMMATION 19 66.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The treatment of H69 human SCLC cells with capsaicin leads to a switch in E2F subtypes on cyclin E, TS, cdc25A and cdc6 promoters; E2F1–3 are dissociated from the promoter, and E2F4 and p130 are recruited.
Localization (recruited) of p130 in H69 associated with qutenza and small cell lung cancer
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.65 Pain Relevance 0.40
Further studies to determine if HCV-infected microglia or astrocytes release infectious viruses will be of interest.
Localization (release) of HCV in astrocytes associated with hepatitis c virus infection
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.74 Pain Relevance 0
The most abundantly expressed HCV protein, core, is released and soluble in blood as a part of HCV morphogenesis [27] and serum levels of HCV core protein ranges from pg/ml to ng/ml [28].
Localization (released) of HCV protein in blood associated with hepatitis c virus infection
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 2.04 Pain Relevance 0.09
In addition to direct neurotoxicity, proinflammatory cytokines and other neurotoxins released from HCV core-activated microglia into supernatants were toxic to neurons.
Localization (released) of HCV in neurons associated with drug induced neurotoxicity, hepatitis c virus infection and cytokine
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.88 Pain Relevance 0.05

General Comments

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