INT306884

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F4) nucleus (E2F4) DNA binding (E2F4)
transcription factor binding (E2F4)
Anatomy Link Frequency
H69 1
E2F4 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 260 97.28 Very High Very High Very High
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 20 88.88 High High
Small Cell Lung Cancer 126 79.32 Quite High
Genomic Instability 2 63.60 Quite High
Non-small-cell Lung Cancer 4 61.76 Quite High
Metastasis 4 52.32 Quite High
Cancer 84 46.56 Quite Low
Breast Cancer 4 20.36 Low Low
Reprotox - General 1 8 19.76 Low Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting analysis showed that the transfection of either sets of E2F4-siRNAs produced efficient suppression of E2F4 protein levels in H69 cells (Fig. 5, C).


Negative_regulation (suppression) of E2F4 in H69
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.28 Pain Relevance 0.41
Our data is consistent with previous studies that have shown that E2F4 is a repressor of transcription and inhibits cell proliferation.
Negative_regulation (repressor) of E2F4
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.34 Pain Relevance 0.21

General Comments

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