INT306910

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.80
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ephx2) Golgi apparatus (Ephx2) nucleolus (Ephx2)
peroxisome (Ephx2) cytoplasm (Ephx2)
Anatomy Link Frequency
plaques 2
lung 2
Ephx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 144 99.96 Very High Very High Very High
fibrosis 24 99.18 Very High Very High Very High
Bile 4 83.92 Quite High
Bioavailability 7 76.40 Quite High
Potency 15 67.76 Quite High
aspirin 6 66.04 Quite High
cINOD 6 65.00 Quite High
cytokine 12 5.00 Very Low Very Low Very Low
cva 9 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 118 99.98 Very High Very High Very High
INFLAMMATION 147 99.96 Very High Very High Very High
Renal Failure 36 99.20 Very High Very High Very High
Fibrosis 40 99.18 Very High Very High Very High
Atherosclerotic Plaque 9 98.20 Very High Very High Very High
Albuminuria 40 94.52 High High
Atherosclerosis 159 92.72 High High
Chronic Renal Failure 40 78.24 Quite High
Disease 35 70.72 Quite High
Renal Disease 28 61.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, also in the lung we previously observed that fibrosis occurring during pulmonary hypertension reduced the sEH expression [9] suggesting that this effect is more important than the previously reported induction of sEH by angiotensin II [46].
Negative_regulation (reduced) of Gene_expression (expression) of sEH in lung associated with fibrosis and hypertension
1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.58 Pain Relevance 0.08
Interestingly, 5/6-Nx also resulted in a marked decrease in the renal expression of the sEH on the protein, as well as on the mRNA level (Fig. 6B).
Negative_regulation (decrease) of Gene_expression (expression) of sEH
2) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.18 Pain Relevance 0.07
In this study we observed that the sEH expression decreases during progressive renal failure.
Negative_regulation (decreases) of Gene_expression (expression) of sEH associated with renal failure
3) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.58 Pain Relevance 0.08
Fig. 2Representative structures of soluble epoxide hydrolase (sEH) inhibitors.
Negative_regulation (inhibitors) of Gene_expression (structures) of soluble epoxide hydrolase
4) Confidence 0.43 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.40 Pain Relevance 0.13
Fig. 2Representative structures of soluble epoxide hydrolase (sEH) inhibitors.
Negative_regulation (inhibitors) of Gene_expression (structures) of sEH
5) Confidence 0.43 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.40 Pain Relevance 0.13
Renal sEH expression was attenuated in 5/6-Nx mice but cAUCB in these animals still further increased the EET-level. cAUCB also increased 5-HETE and 15-HETE, which derive from peroxidation or lipoxygenases.
Negative_regulation (attenuated) of Gene_expression (expression) of sEH
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2915917 Disease Relevance 0.92 Pain Relevance 0.03
Inhibitors of sEH reduce inflammation and prevent the development of atherosclerotic plaques, presumably via an increase in EETs and other epoxy lipids, as well as a decrease in the corresponding diols [3••, 4••].
Negative_regulation (Inhibitors) of Gene_expression (reduce) of sEH in plaques associated with atherosclerotic plaque and inflammation
7) Confidence 0.37 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.73 Pain Relevance 0.15

General Comments

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