INT30693

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Context Info
Confidence 0.36
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.76
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ggt1) aging (Ggt1) transferase activity, transferring acyl groups (Ggt1)
Anatomy Link Frequency
BBM 1
Ggt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 2 88.08 High High
withdrawal 1 75.56 Quite High
Angina 4 74.36 Quite High
Paracetamol 1 56.56 Quite High
Bioavailability 1 49.20 Quite Low
antidepressant 114 46.56 Quite Low
Pain 74 35.32 Quite Low
sNRI 50 33.92 Quite Low
Pain score 2 19.60 Low Low
depression 86 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 8 98.76 Very High Very High Very High
Body Weight 4 92.72 High High
Weight Loss 4 91.00 High High
Congenital Anomalies 4 82.00 Quite High
Pressure And Volume Under Development 4 75.72 Quite High
Angina 4 74.36 Quite High
Dystonia 2 70.56 Quite High
Suicidal Behaviour 8 69.60 Quite High
Hepatotoxicity 2 61.08 Quite High
Death 10 57.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Statistically significant increases from baseline to end point were observed for the following laboratory values: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), bilirubin alkaline phosphatase, fasting total cholesterol, and fasting triglycerides.
GGT Binding (bilirubin) of associated with disorder of lipid metabolism
1) Confidence 0.36 Published 2010 Journal Core evidence Section Body Doc Link PMC2899788 Disease Relevance 0.81 Pain Relevance 0.07
Hepatic GGT activity was increased slightly, but not significantly, whereas renal GGT activity was similar in ethanol-fed rats.
GGT Binding (activity) of
2) Confidence 0.35 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 2871842 Disease Relevance 0.12 Pain Relevance 0.09
Statistically significant increases from baseline to end point were observed for the following laboratory values: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), bilirubin alkaline phosphatase, fasting total cholesterol, and fasting triglycerides.
gamma-glutamyl transferase Binding (bilirubin) of associated with disorder of lipid metabolism
3) Confidence 0.12 Published 2010 Journal Core evidence Section Body Doc Link PMC2899788 Disease Relevance 0.82 Pain Relevance 0.07
These dietary spices stimulated the activities of BBM enzymes (glycyl-glycine dipeptidase, leucine amino peptidase and gamma-glutamyl transpeptidase) in the jejunal mucosa, suggesting a modulation in membrane dynamics due to the apolar spice bioactive compounds interacting with surrounding lipids and hydrophobic portions in the protein vicinity, which may decrease the tendency of membrane lipids to act as steric constraints to enzyme proteins and thus modify enzyme conformation.
transpeptidase Binding (activities) of in BBM
4) Confidence 0.02 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 20178671 Disease Relevance 0 Pain Relevance 0.09

General Comments

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