INT306941

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.65
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfsf12, CCL2) extracellular region (Tnfsf12, CCL2) cell differentiation (Tnfsf12)
aging (CCL2) cytoplasm (CCL2) signal transduction (CCL2)
Anatomy Link Frequency
kidney 2
Tnfsf12 (Mus musculus)
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 4 100.00 Very High Very High Very High
Inflammatory mediators 1 100.00 Very High Very High Very High
Inflammation 11 96.16 Very High Very High Very High
cytokine 2 65.20 Quite High
rheumatoid arthritis 3 5.76 Low Low
Arthritis 5 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 100.00 Very High Very High Very High
Renal Disease 114 92.92 High High
Injury 6 89.36 High High
Apoptosis 10 83.76 Quite High
Death 1 83.20 Quite High
Systemic Lupus Erythematosus 86 80.80 Quite High
Hyperplasia 1 75.44 Quite High
Necrosis 2 62.04 Quite High
Cancer 2 61.68 Quite High
Nephritis 17 53.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is recently shown that ex vivo stimulation of murine and human kidney cells by TWEAK induces the expression of chemokines and inflammatory mediators such as MCP-1, RANTES, IFN-gamma-induced protein 10 (IP-10), ICAM-1, and VCAM-1 [34, 35], which are relevant to the induction of inflammation through cellular recruitment and progression of lupus nephritis.
TWEAK Positive_regulation (induces) of Gene_expression (expression) of MCP-1 in kidney associated with chemokine, inflammatory mediators, inflammation and renal disease
1) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.65 Pain Relevance 0.27

General Comments

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