INT307

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Context Info
Confidence 0.42
First Reported 1976
Last Reported 2007
Negated 3
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 4.57
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger1) signal transducer activity (Ptger1)
Anatomy Link Frequency
PGE1 3
plasma 1
neuronal 1
glial cells 1
spinal cord 1
Ptger1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
adenocard 4 99.90 Very High Very High Very High
Spinal cord 5 99.28 Very High Very High Very High
antagonist 7 99.04 Very High Very High Very High
fluoxetine 1 98.14 Very High Very High Very High
opiate 2 97.06 Very High Very High Very High
Dopamine 10 96.84 Very High Very High Very High
peptic ulcer disease 1 92.56 High High
rheumatoid arthritis 2 87.68 High High
anesthesia 7 86.56 High High
Disease Link Frequency Relevance Heat
Fever 6 99.96 Very High Very High Very High
Solid Tumor 3 99.12 Very High Very High Very High
Nociception 4 98.52 Very High Very High Very High
Hypotension 4 98.40 Very High Very High Very High
Ulcers 18 98.16 Very High Very High Very High
Cancer 60 97.44 Very High Very High Very High
Increased Venous Pressure Under Development 4 96.68 Very High Very High Very High
Disease 5 96.16 Very High Very High Very High
Pressure Volume 2 Under Development 1 94.68 High High
Galactorrhea 2 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was designed to investigate the roles of PGE2 and EP1 receptors in the spinal cord in the nociceptive transmission, using behavioral and intracellular calcium ion concentration ([Ca2+]i) assays and in situ hybridization.
Spec (investigate) Regulation (roles) of EP1 in spinal cord associated with nociception and spinal cord
1) Confidence 0.42 Published 2004 Journal Brain Res. Section Abstract Doc Link 15126118 Disease Relevance 0.33 Pain Relevance 0.27
On the other hand, EP1 electric pulses have already been shown to be effective for gene delivery of solid tumors of different histology and origin (rat, mouse and human) [5].
Regulation (effective) of EP1 associated with solid tumor
2) Confidence 0.31 Published 2004 Journal BMC Cancer Section Body Doc Link PMC534104 Disease Relevance 0.67 Pain Relevance 0.04
The major structural alteration of PGE1 was the relocation of the 15-hydroxy group to the adjacent 16-position.
Regulation (alteration) of PGE1 in PGE1
3) Confidence 0.21 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3932041 Disease Relevance 0.27 Pain Relevance 0.17
It could be concluded that the eosinopenic effect of PGE1 and PGF2alpha was conducted through the hypothalamus and adrenal glands, but that of PGE2 might be effected through the hypophysis or directly through the adrenal glands.
Regulation (effect) of PGE1 in hypophysis
4) Confidence 0.21 Published 1976 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 1035171 Disease Relevance 0 Pain Relevance 0.07
Efficacy of prostaglandin E1 in the treatment of lower extremity ischemic ulcers secondary to peripheral vascular occlusive disease.
Regulation (Efficacy) of prostaglandin E1 in extremity associated with pain, ulcers and disease
5) Confidence 0.16 Published 1984 Journal J. Vasc. Surg. Section Title Doc Link 6384558 Disease Relevance 1.25 Pain Relevance 0.17
The potentiation of the beta-adrenoceptor and PGE1 responses suggests that they may occur in glial cells.
Regulation (responses) of PGE1 in glial cells
6) Confidence 0.08 Published 1978 Journal Brain Res. Section Abstract Doc Link 27287 Disease Relevance 0 Pain Relevance 0.33
The influence of prostaglandin E1 (PGE1) on PaO2 at doses that produced slight hypotension was evaluated in 176 patients scheduled for surgery.
Regulation (influence) of PGE1 in PGE1 associated with hypotension
7) Confidence 0.07 Published 1993 Journal Masui Section Abstract Doc Link 8468782 Disease Relevance 0.24 Pain Relevance 0.16
Some dopamine and opiate receptors, as well as most of the phosphodiesterase activity, are associated with local neuronal elements, while beta-adrenoceptor, adenosine and PGE1 alterations in cyclic AMP are not.
Regulation (alterations) of PGE1 in neuronal associated with adenocard, dopamine and opiate
8) Confidence 0.04 Published 1978 Journal Brain Res. Section Abstract Doc Link 27287 Disease Relevance 0 Pain Relevance 0.35
In this study, we used near infrared spectrometry and jugular oxygen saturation measurement to assess the effects of prostaglandin E1 and nitroglycerin on cerebral perfusion.
Regulation (effects) of prostaglandin E1
9) Confidence 0.03 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9356099 Disease Relevance 0.23 Pain Relevance 0.04
This retrospective, observational study was performed to compare the efficacy of PGE1 and PLC, and to evaluate both the immediate results of an intensive, short-course rehabilitation program and the outcome at one year follow-up.
Regulation (efficacy) of PGE1 in PGE1
10) Confidence 0.02 Published 2007 Journal Monaldi Arch Chest Dis Section Abstract Doc Link 17886772 Disease Relevance 0.26 Pain Relevance 0.07
As to the molecular mechanisms of the pathogenesis, the intracellular affects of prolactin or prostaglandin PGE1 are important.
Regulation (affects) of PGE1
11) Confidence 0.01 Published 1980 Journal Med. Hypotheses Section Abstract Doc Link 7001193 Disease Relevance 0.58 Pain Relevance 0.12
There was a slight fall in skin reactivity to UV light during the treatment, but no effect on plasma or urine concentrations of PGE1, cAMP or cGMP.
Neg (no) Regulation (effect) of PGE1 in plasma
12) Confidence 0.01 Published 1983 Journal Scand. J. Rheumatol. Section Abstract Doc Link 6304871 Disease Relevance 0.16 Pain Relevance 0.17
No effect of PGE1 or PGE2 could be detected on the time course of basal or LH-RH-stimulated LH release or on the LH responsiveness to LH-RH.
Neg (No) Regulation (effect) of PGE1
13) Confidence 0.01 Published 1976 Journal Prostaglandins Section Abstract Doc Link 772758 Disease Relevance 0 Pain Relevance 0.11
Prostaglandin E2 (PGE2) exerts its biological effects through 4 different receptor subtypes, EP-1, EP-2, EP-3, and EP-4.
Regulation (effects) of EP-1 in PGE2
14) Confidence 0.01 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15519499 Disease Relevance 0.14 Pain Relevance 0.18
However, the 5-HT reuptake blocker, fluoxetine, and the beta-adrenergic receptor antagonist, propranolol, injected in the AH/POA failed to alter the PGE1 hyperthermia.
Neg (failed) Regulation (alter) of PGE1 associated with antagonist, fever and fluoxetine
15) Confidence 0.00 Published 1994 Journal Neurosci Biobehav Rev Section Abstract Doc Link 7909592 Disease Relevance 0.45 Pain Relevance 0.47

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