INT307046

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
brain 1
Tmie (Mus musculus)
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 10 98.72 Very High Very High Very High
Cannabinoid 47 95.76 Very High Very High Very High
agonist 24 95.28 Very High Very High Very High
Cannabinoid receptor 8 88.52 High High
Nucleus accumbens 2 70.00 Quite High
Central grey 1 60.00 Quite High
Dopamine 24 57.28 Quite High
dopamine receptor 1 25.20 Quite Low
Nicotine 2 13.52 Low Low
cocaine 4 11.68 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 3 98.48 Very High Very High Very High
Targeted Disruption 3 97.48 Very High Very High Very High
Urological Neuroanatomy 1 60.00 Quite High
Stress 2 41.20 Quite Low
Recurrence 3 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Psychosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a similar way to WIN, SR 141716 is reported to exhibit an independent CB1 activity; for instance, it exerts an anxiolytic effect on CB1 knockout mice [30] The aversive effects of cannabinoid agonists observed in many studies, and the rewarding effect of cannabinoid antagonists are suggestive of a cannabinergic tone in the rat brain.
SR Neg (independent) Positive_regulation (exhibit) of CB1 in brain associated with targeted disruption, antagonist, cannabinoid, anxiety disorder and agonist
1) Confidence 0.05 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2858089 Disease Relevance 0.31 Pain Relevance 0.69

General Comments

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