INT307060

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.79
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AKTIP) cytoplasm (AKTIP)
Anatomy Link Frequency
thyroid 1
pituitary 1
AKTIP (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 22 89.36 High High
Bioavailability 25 71.04 Quite High
biopsychosocial 7 50.00 Quite Low
Somatostatin 5 37.44 Quite Low
Clonidine 5 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypothyroidism 45 98.32 Very High Very High Very High
Thyroid Disease 140 95.52 Very High Very High Very High
Thyroiditis 6 93.92 High High
Constipation 1 92.56 High High
Heart Rate Under Development 1 92.00 High High
Hoarseness 1 91.08 High High
Disease 10 91.04 High High
Weight Gain 1 90.60 High High
Depression 24 89.36 High High
Fatigue 1 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phenomenon of T4 and FT4 concentration decrease after rhGH administration in GH-deficient subjects has been reported in several studies [1,2,5,9,12,14].
Negative_regulation (decrease) of FT4
1) Confidence 0.01 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.29 Pain Relevance 0
The decrease of free thyroxine (FT4) levels at recombinant human GH (rhGH) therapy onset has been reported in several studies.
Negative_regulation (decrease) of FT4
2) Confidence 0.01 Published 2010 Journal Thyroid Res Section Abstract Doc Link PMC2858102 Disease Relevance 0 Pain Relevance 0
In our study, in 15% of previously euthyroid children, a decrease of FT4 level with no adequate increase of TSH was observed, (it should be stressed that children with evident central hypothyroidism before rhGH administration, being a component of multiple pituitary hormone deficiency, were not included in current study).
Negative_regulation (decrease) of FT4 in pituitary associated with thyroid disease
3) Confidence 0.01 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.56 Pain Relevance 0
Among the patients who had L-T4 substitution, administered before rhGH therapy onset, the decrease of FT4 below the lower limit of normal range was observed in 2 out of 8 cases and in those children, an increased dose of L-T4 was necessary to restore euthyroidism.
Negative_regulation (decrease) of FT4
4) Confidence 0.01 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0 Pain Relevance 0.04
Similar were the observations of Losa et al. [5], who reported that, in adults with GHD, administration of rhGH therapy was associated with a significant decrease of free T4 (FT4) in first 6 months of treatment.
Negative_regulation (decrease) of FT4
5) Confidence 0.01 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.24 Pain Relevance 0
Laboratory testing in individuals with primary overt hypothyroidism typically depicts an elevated serum thyroid stimulating hormone (TSH) level, and a decrease in serum free-thyroxine (FT4) levels [3].
Negative_regulation (decrease) of FT4 in thyroid associated with hypothyroidism
6) Confidence 0.00 Published 2010 Journal Trials Section Body Doc Link PMC2992059 Disease Relevance 1.70 Pain Relevance 0.04

General Comments

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