INT307065

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.78
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bowel 3
Slc10a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 8 95.84 Very High Very High Very High
Inflammatory response 4 13.44 Low Low
Inflammation 8 6.56 Low Low
Potency 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
positron emission tomography 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Radiation Sickness 8 98.44 Very High Very High Very High
Rectal Cancer 108 96.52 Very High Very High Very High
Recurrence 48 90.44 High High
Metastasis 16 87.00 High High
Gastrointestinal Neoplasms 4 72.08 Quite High
Cancer 48 64.44 Quite High
Cicatrix 8 56.16 Quite High
Hypoxia 28 53.60 Quite High
Malignant Neoplastic Disease 48 51.92 Quite High
Head & Neck Cancer 12 51.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, although NTCP which reflects account all the DVH data was not increased, Dmax of small bowel PRV in the summed plan using focal dose escalation was significantly higher than that in other summed plans.
Neg (not) Positive_regulation (increased) of NTCP in bowel
1) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2858110 Disease Relevance 0.35 Pain Relevance 0.04
In the present study, although Dmax of small bowel PRV of summed plan 3 was slightly higher than that of summed plan 1 or summed plan 2, V50 of small bowel PRV could be reduced by IMRT, and V30, V40, V60, Dmean and NTCP were not increased even using focal dose escalation.
Positive_regulation (increased) of NTCP in bowel
2) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2858110 Disease Relevance 0.63 Pain Relevance 0
In the present study, since V30, V40, V60, Dmean and NTCP of small bowel PRV were not increased and V50 of small bowel PRV could be reduced due to the differences between GTV2 and BTV, focal dose escalation by 6 Gy to regions with SUV above 2.0 using IMRT with dose-painting boost for postoperative local recurrent rectal cancer is considered to be safe.
Neg (not) Positive_regulation (increased) of NTCP in bowel associated with rectal cancer
3) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2858110 Disease Relevance 0.48 Pain Relevance 0.05
MM and NM verified and calculated DVH and NTCP.
Positive_regulation (calculated) of NTCP
4) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2858110 Disease Relevance 0.31 Pain Relevance 0

General Comments

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