INT307138

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppig) protein folding (Ppig) nucleus (Ppig)
cytoplasm (Ppig)
Anatomy Link Frequency
plasma 2
Ppig (Mus musculus)
Pain Link Frequency Relevance Heat
depression 8 100.00 Very High Very High Very High
Inflammation 23 99.12 Very High Very High Very High
fibrosis 6 62.36 Quite High
Inflammatory stimuli 2 39.44 Quite Low
cytokine 2 7.04 Low Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 8 100.00 Very High Very High Very High
Renal Failure 9 99.64 Very High Very High Very High
INFLAMMATION 26 99.12 Very High Very High Very High
Immunization 2 98.72 Very High Very High Very High
Asthma 1 84.60 Quite High
Malaria 45 68.16 Quite High
Fibrosis 10 62.36 Quite High
Bacterial Infection 1 50.80 Quite High
Albuminuria 10 50.00 Quite Low
Disease 8 47.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonetheless, the idea that NO mediates a general depression of CYP activities caused by inflammatory and infectious stimuli remains controversial.
Positive_regulation (mediates) of Negative_regulation (depression) of CYP associated with inflammation and depression
1) Confidence 0.06 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.54 Pain Relevance 0.10
Given the low plasma concentrations of EETs, it is however difficult to imagine that the somewhat modest increase in response to sEH inhibition or renal failure is sufficient to induce a significant product inhibition of the CYP enzymes, although other observations supporting the complex crosstalk have been published for inflammatory models [45].
Positive_regulation (induce) of Negative_regulation (inhibition) of CYP in plasma associated with inflammation and renal failure
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.47 Pain Relevance 0.08

General Comments

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