INT307141
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The idea that NO is a mediator of the down-modulation of CYP expression by inflammatory stimuli is plausible because NO binds haem proteins and inhibits catalytic activities of CYPs in in vitro test systems [16,17]. | |||||||||||||||
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EET levels are dependent on the activity and expression of the CYP epoxygenases, which generate them and the enzyme soluble epoxide hydrolase (sEH) which converts the EETs to their corresponding dihydroxyeicosatrienoic acids (DHETs) [3]. | |||||||||||||||
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The mechanism by which malaria down-modulates the expression and activity of other CYP isoforms is still unclear. | |||||||||||||||
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General Comments
This test has worked.