INT307141

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.84
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppig) protein folding (Ppig) nucleus (Ppig)
cytoplasm (Ppig)
Ppig (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 4 99.84 Very High Very High Very High
Bioavailability 3 91.56 High High
Inflammation 28 90.24 High High
Inflammatory response 2 82.80 Quite High
depression 16 76.12 Quite High
cytokine 4 18.08 Low Low
fibrosis 6 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 90 99.88 Very High Very High Very High
INFLAMMATION 34 99.84 Very High Very High Very High
Infection 124 96.40 Very High Very High Very High
Disease 11 90.56 High High
Communicable Diseases 2 88.64 High High
Depression 16 76.12 Quite High
Targeted Disruption 3 71.36 Quite High
Hypertension 19 56.32 Quite High
Albuminuria 10 50.00 Quite Low
Sprains And Strains 32 40.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The idea that NO is a mediator of the down-modulation of CYP expression by inflammatory stimuli is plausible because NO binds haem proteins and inhibits catalytic activities of CYPs in in vitro test systems [16,17].
Regulation (modulation) of Gene_expression (expression) of CYP associated with inflammatory stimuli
1) Confidence 0.08 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.58 Pain Relevance 0.13
EET levels are dependent on the activity and expression of the CYP epoxygenases, which generate them and the enzyme soluble epoxide hydrolase (sEH) which converts the EETs to their corresponding dihydroxyeicosatrienoic acids (DHETs) [3].
Regulation (dependent) of Gene_expression (expression) of CYP
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.29 Pain Relevance 0.15
The mechanism by which malaria down-modulates the expression and activity of other CYP isoforms is still unclear.
Regulation (modulates) of Gene_expression (expression) of CYP associated with malaria
3) Confidence 0.03 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.98 Pain Relevance 0.15

General Comments

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