INT307151

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppig) protein folding (Ppig) nucleus (Ppig)
cytoplasm (Ppig)
Anatomy Link Frequency
liver 2
Ppig (Mus musculus)
Pain Link Frequency Relevance Heat
depression 16 100.00 Very High Very High Very High
Inflammation 10 99.84 Very High Very High Very High
Inflammatory stimuli 4 42.92 Quite Low
cytokine 4 10.52 Low Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 16 100.00 Very High Very High Very High
INFLAMMATION 16 99.84 Very High Very High Very High
Immunization 4 99.84 Very High Very High Very High
Malaria 90 71.64 Quite High
Bacterial Infection 2 52.24 Quite High
Injury 10 48.32 Quite Low
Infection 124 41.92 Quite Low
Parasitic Infection 2 38.24 Quite Low
Stress 58 5.00 Very Low Very Low Very Low
Sprains And Strains 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these findings, and also on in vivo experiments in which iNOS inhibitors partially reversed LPS-induced decline of liver CYP activities, Khatsenko et al [16] advanced a hypothesis that NO overproduction mediates the decrease in CYP activities induced by immunostimulation.
Negative_regulation (decrease) of Positive_regulation (induced) of CYP in liver associated with immunization
1) Confidence 0.07 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.48 Pain Relevance 0.09
Nonetheless, the idea that NO mediates a general depression of CYP activities caused by inflammatory and infectious stimuli remains controversial.
Negative_regulation (depression) of Positive_regulation (caused) of CYP associated with inflammation and depression
2) Confidence 0.05 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.54 Pain Relevance 0.10

General Comments

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