INT307154

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.47 Pain Relevance 0.08

isomerase activity (Ppig) protein folding (Ppig) nucleus (Ppig) cytoplasm (Ppig)

Anatomy Link Frequency liver 2 Ppig (Mus musculus)

Pain Link Frequency Relevance Heat depression 8 84.16 Inflammation 5 81.04 Inflammatory stimuli 2 48.24 cytokine 2 15.84 Paracetamol 2 5.00 Bile 1 5.00 Inflammatory response 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat Immunization 2 94.80 Depression 8 84.16 INFLAMMATION 8 81.04 Malaria 45 76.96 Injury 5 53.64 Infection 62 47.24 Bacterial Infection 1 33.60 Parasitic Infection 1 19.60 Stress 29 9.44 Sprains And Strains 15 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Based on these findings, and also on in vivo experiments in which iNOS inhibitors partially reversed LPS-induced decline of liver CYP activities, Khatsenko et al [16] advanced a hypothesis that NO overproduction mediates the decrease in CYP activities induced by immunostimulation.

Negative_regulation (reversed) of Negative_regulation (decline) of CYP in liver associated with immunization

1) Confidence 0.06 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.47 Pain Relevance 0.08

General Comments

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