INT307186

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.91
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
T cells 2
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 1 95.48 Very High Very High Very High
cytokine 44 91.28 High High
Inflammation 67 90.88 High High
Inflammatory response 17 83.12 Quite High
rheumatoid arthritis 1 76.20 Quite High
Central nervous system 3 67.20 Quite High
tolerance 2 48.64 Quite Low
Multiple sclerosis 2 39.36 Quite Low
agonist 18 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 2 93.08 High High
Cancer 38 92.72 High High
INFLAMMATION 84 90.88 High High
Atherosclerotic Plaque 4 86.20 High High
Apoptosis 17 84.28 Quite High
Rheumatoid Arthritis 1 76.20 Quite High
Hepatocellular Cancer 11 76.00 Quite High
Diabetes Mellitus 4 75.00 Quite High
Autoimmune Disease 4 74.24 Quite High
Myeloid Leukemia 8 73.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTPH1 overexpression in Jurkat T cells reduces indirectly the TCR-induced serine phosphorylation of Mek, Erk, Jnk and AP-1 leading to a decreased IL-2 gene activation [13].
Negative_regulation (reduces) of Phosphorylation (phosphorylation) of AP-1 in T cells
1) Confidence 0.10 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.23 Pain Relevance 0.04
B) and decreasing phosphorylation of the c-jun subunit of AP-1 [Ramanan et al., 2008].
Negative_regulation (decreasing) of Phosphorylation (phosphorylation) of c-jun subunit
2) Confidence 0.06 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 1.00 Pain Relevance 0.26
B) and decreasing phosphorylation of the c-jun subunit of AP-1 [Ramanan et al., 2008].
Negative_regulation (decreasing) of Phosphorylation (phosphorylation) of AP-1
3) Confidence 0.06 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 1.01 Pain Relevance 0.26
-catenin and on the other hand, in the inhibition of c-jun phosphorylation leading to an increase in the DNA binding activity of AP-1.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of c-jun
4) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.68 Pain Relevance 0.05

General Comments

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