INT307187

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.11
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ncoa1) nucleus (Ncoa1) transferase activity, transferring acyl groups (Ncoa1)
DNA binding (Ncoa1) signal transducer activity (Ncoa1)
Anatomy Link Frequency
brown fat 1
fat 1
Ncoa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 36 50.00 Quite Low
agonist 18 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Embryonic Lethality 6 57.68 Quite High
INFLAMMATION 48 50.00 Quite Low
Cancer 12 50.00 Quite Low
Hypolipidemia 2 50.00 Quite Low
Targeted Disruption 32 30.88 Quite Low
Liver Cancer 32 5.00 Very Low Very Low Very Low
Obesity 26 5.00 Very Low Very Low Very Low
Stress 20 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 18 5.00 Very Low Very Low Very Low
Liver Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of both p/CIP/SRC-3 and SRC-1 also leads to increased food intake on both regular chow and a high-fat diet, indicating excess energy burning [Wang et al., 2006].
Negative_regulation (Loss) of SRC-1 in fat
1) Confidence 0.08 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.06 Pain Relevance 0
Combined loss of p/CIP/SRC-3 and SRC-1 function has been shown to lead to a specific block in brown fat development, in part due to a failure of induction of PPAR?
Negative_regulation (loss) of SRC-1 in brown fat
2) Confidence 0.04 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.06 Pain Relevance 0

General Comments

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