INT307200

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.72
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nrip1)
Anatomy Link Frequency
fat 1
Nrip1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 26 50.00 Quite Low
Eae 14 40.80 Quite Low
agonist 9 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 96 99.96 Very High Very High Very High
Obesity 251 99.00 Very High Very High Very High
INFLAMMATION 34 50.00 Quite Low
Cancer 8 50.00 Quite Low
Hypolipidemia 1 50.00 Quite Low
Body Weight 48 5.00 Very Low Very Low Very Low
Liver Cancer 16 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 13 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low
Insulin Resistance 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data are in line with previous studies in humans [50], supporting the notion that downregulation of Rip140 may be a compensatory mechanism in order to favour energy expenditure and fat accumulation reduction in already established obese states.
Negative_regulation (downregulation) of Rip140 in fat associated with obesity
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.67 Pain Relevance 0
Moreover, the corepressor Rip140, that plays a key role in energy homeostasis by repressing metabolic gene networks [49], was dramatically reduced in iNOS knockout and ob/ob mice.
Negative_regulation (reduced) of Rip140 associated with targeted disruption and obesity
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.86 Pain Relevance 0
Interestingly, the phenotype of RIP140 knockout mice suggests a role for this corepressor in PPAR?
Negative_regulation (phenotype) of RIP140 associated with targeted disruption
3) Confidence 0.26 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.19 Pain Relevance 0

General Comments

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