INT307233

Context Info Confidence 0.19 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.84 Pain Relevance 0.11

nucleus (BCL3) protein binding, bridging (BCL3) extracellular matrix organization (BCL3) protein complex (BCL3) transcription factor binding (BCL3) cytoplasm (BCL3)

Anatomy Link Frequency nucleus 2 BCL3 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 2 59.20 Inflammation 10 5.00 cytokine 4 5.00 Inflammatory mediators 2 5.00 psoriasis 2 5.00

Disease Link Frequency Relevance Heat Hyperplasia 14 97.84 Cholesteatoma 120 68.48 Apoptosis 24 66.32 INFLAMMATION 14 58.96 Colon Cancer 2 54.44 Hepatocellular Cancer 2 53.76 Carcinoma 2 52.40 Rheumatoid Arthritis 48 27.60 Cancer 10 5.00 Skin Cancer 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

After translocation of Bcl-3 from the cytoplasm to the perinuclear region, CYLD removes K63-linked polyubiquitin chains from Bcl-3, and thus prevents translocation of Bcl-3 into the nucleus [10].

Localization (translocation) of Bcl-3 in nucleus

1) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.50 Pain Relevance 0.06

After translocation of Bcl-3 from the cytoplasm to the perinuclear region, CYLD removes K63-linked polyubiquitin chains from Bcl-3, and thus prevents translocation of Bcl-3 into the nucleus [10].

Localization (translocation) of Bcl-3 in nucleus

2) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.33 Pain Relevance 0.05

General Comments

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