INT307240

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.09
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural constituent of ribosome (CYLD) ribosome (CYLD) intracellular (CYLD)
cytoplasm (CYLD) cytosol (CYLD) peptidase activity (CYLD)
Anatomy Link Frequency
liver 1
CYLD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 70.48 Quite High
cytokine 6 69.76 Quite High
psoriasis 3 15.48 Low Low
Pain 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 8 99.48 Very High Very High Very High
Cholesteatoma 180 98.88 Very High Very High Very High
Rheumatoid Arthritis 72 94.36 High High
Stress 29 85.12 High High
Poisoning 32 82.72 Quite High
Cancer 25 81.88 Quite High
Apoptosis 41 77.52 Quite High
INFLAMMATION 24 70.48 Quite High
Death 11 68.08 Quite High
Hypercalcemia 6 65.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm the colocalization of CYLD and NF-?
Localization (colocalization) of CYLD
1) Confidence 0.72 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.11 Pain Relevance 0
B, we examined the correlation between CYLD and activated NF-?
Spec (examined) Localization (correlation) of CYLD
2) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 1.08 Pain Relevance 0
We found a significant inverse correlation between CYLD and NF-?
Localization (correlation) of CYLD
3) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 1.33 Pain Relevance 0.10
NAC besides preventing hepatotoxicity and reducing the rate of CdMT release from the liver, protect directly by forming a complex with Cd [135], or indirectly by scavenging free radicals [136] or by serving as a cysteine donor for GSH synthesis.


Localization (release) of CdMT in liver associated with hepatotoxicity
4) Confidence 0.09 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2922724 Disease Relevance 0.58 Pain Relevance 0

General Comments

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