INT307250

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.71
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx3) Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 6
P2rx3 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 11 93.36 High High
agonist 29 92.96 High High
TRP channel 1 91.60 High High
Kinase C 1 88.48 High High
Glutamate receptor 1 86.72 High High
Potency 6 84.40 Quite High
Pain 53 78.28 Quite High
imagery 8 71.36 Quite High
nociceptor 81 64.72 Quite High
antagonist 8 60.64 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 65 99.96 Very High Very High Very High
Pain 58 78.28 Quite High
Neurological Disease 2 71.80 Quite High
Ganglion Cysts 22 50.00 Quite Low
INFLAMMATION 15 50.00 Quite Low
Migraine With Aura 10 50.00 Quite Low
Neuropathic Pain 44 5.00 Very Low Very Low Very Low
Migraine Disorders 26 5.00 Very Low Very Low Very Low
Inflammatory Pain 19 5.00 Very Low Very Low Very Low
Depression 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, our data indicate a major gain of function of P2X3 receptors without their concomitant overexpression at the plasma membrane or a larger number of P2X3 receptor expressing neurons.
Negative_regulation (number) of Gene_expression (expressing) of P2X3 in neurons
1) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.22 Pain Relevance 0.47
Although significant, this difference was not very large probably because the number of P2X3 receptor expressing neurons that also expressed CaV2.1 channels was less than 50% of the total population whose contribution diluted the overall change (see Fig. 3F).
Negative_regulation (number) of Gene_expression (expressing) of P2X3 in neurons
2) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
Here we found that high level Ret expression and P2X3 expression were completely eliminated in IB4+ neurons in L-CKO mice (Fig. 1B), whereas their expression in IB4-negative neurons was largely unaffected (Fig. 1B).
Negative_regulation (eliminated) of Gene_expression (expression) of P2X3 in neurons
3) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.18 Pain Relevance 0.40
Previous studies have shown that small intestinal peristalsis studied in vitro is impaired tissues from P2X2 and P2X3 KO mice (Bian et al., 2003; Ren et al., 2003).
Negative_regulation (impaired) of Gene_expression (tissues) of P2X3 associated with targeted disruption
4) Confidence 0.30 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.32 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox