INT307250

Context Info Confidence 0.40 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.71 Pain Relevance 0.87

transport (P2rx3) Golgi apparatus (P2rx3)

Anatomy Link Frequency neurons 6 P2rx3 (Mus musculus)

Pain Link Frequency Relevance Heat qutenza 11 93.36 agonist 29 92.96 TRP channel 1 91.60 Kinase C 1 88.48 Glutamate receptor 1 86.72 Potency 6 84.40 Pain 53 78.28 imagery 8 71.36 nociceptor 81 64.72 antagonist 8 60.64

Disease Link Frequency Relevance Heat Targeted Disruption 65 99.96 Pain 58 78.28 Neurological Disease 2 71.80 Ganglion Cysts 22 50.00 INFLAMMATION 15 50.00 Migraine With Aura 10 50.00 Neuropathic Pain 44 5.00 Migraine Disorders 26 5.00 Inflammatory Pain 19 5.00 Depression 14 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, our data indicate a major gain of function of P2X3 receptors without their concomitant overexpression at the plasma membrane or a larger number of P2X3 receptor expressing neurons.

Negative_regulation (number) of Gene_expression (expressing) of P2X3 in neurons

1) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.22 Pain Relevance 0.47

Although significant, this difference was not very large probably because the number of P2X3 receptor expressing neurons that also expressed CaV2.1 channels was less than 50% of the total population whose contribution diluted the overall change (see Fig. 3F).

Negative_regulation (number) of Gene_expression (expressing) of P2X3 in neurons

2) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0

Here we found that high level Ret expression and P2X3 expression were completely eliminated in IB4+ neurons in L-CKO mice (Fig. 1B), whereas their expression in IB4-negative neurons was largely unaffected (Fig. 1B).

Negative_regulation (eliminated) of Gene_expression (expression) of P2X3 in neurons

3) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.18 Pain Relevance 0.40

Previous studies have shown that small intestinal peristalsis studied in vitro is impaired tissues from P2X2 and P2X3 KO mice (Bian et al., 2003; Ren et al., 2003).

Negative_regulation (impaired) of Gene_expression (tissues) of P2X3 associated with targeted disruption

4) Confidence 0.30 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.32 Pain Relevance 0

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