INT307299

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DCP2) RNA binding (DCP2) nucleus (DCP2)
cytoplasm (DCP2)
Anatomy Link Frequency
terminal segment 2
DCP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 28 52.84 Quite High
Neuritis 28 16.84 Low Low
Peripheral nervous system 42 5.00 Very Low Very Low Very Low
Spinal cord 14 5.00 Very Low Very Low Very Low
Demyelination 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 49 31.32 Quite Low
Experimental Autoimmune Neuritis 28 16.84 Low Low
Demyelinating Disease 21 5.00 Very Low Very Low Very Low
Sprains And Strains 14 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Chronic Inflammatory Demyelinating Polyradiculoneuropathy 14 5.00 Very Low Very Low Very Low
Polyradiculoneuropathy 7 5.00 Very Low Very Low Very Low
Nervous System Injury 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate direct binding of the peptide to DPC micelles.
DPC Binding (binding) of
1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858655 Disease Relevance 0 Pain Relevance 0
The His-tagged protein was used only for three experiments: for a comparison of tagged and non-tagged protein by SRCD, and the fluorescence assays of DPC interaction (alongside with the non-tagged protein) and cholesterol binding.


DPC Binding (interaction) of
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858655 Disease Relevance 0 Pain Relevance 0
The interaction with DPC was also probed by fluorescence spectroscopy, using the intrinsic signal from the Trp residue within the peptide (Figure 5C).
DPC Binding (interaction) of
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858655 Disease Relevance 0 Pain Relevance 0
However, whether this is a result of the N-terminal segment binding to DPC micelles, of the binding of monomeric DPC inside P2, or both, remains a subject for future studies.


DPC Binding (binding) of in terminal segment
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858655 Disease Relevance 0 Pain Relevance 0
We synthesized a peptide corresponding to this putative membrane binding region and studied its conformation upon binding to membrane mimics, such as DPC micelles, using SRCD (Figure 5B).
DPC Binding (binding) of
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858655 Disease Relevance 0 Pain Relevance 0.03
However, whether this is a result of the N-terminal segment binding to DPC micelles, of the binding of monomeric DPC inside P2, or both, remains a subject for future studies.


DPC Binding (binding) of in terminal segment
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858655 Disease Relevance 0 Pain Relevance 0
Since the peptide contains a Trp residue, intrinsic fluorescence spectroscopy was used to study its binding to dodecylphosphocholine (DPC) micelles.
DPC Binding (binding) of
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858655 Disease Relevance 0 Pain Relevance 0

General Comments

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