INT307306

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COMP, CALR) extracellular region (COMP, CALR) proteinaceous extracellular matrix (COMP, CALR)
unfolded protein binding (CALR) Golgi apparatus (CALR) endoplasmic reticulum (CALR)
COMP (Homo sapiens)
CALR (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 26 99.32 Very High Very High Very High
Chondrosarcoma 24 99.24 Very High Very High Very High
Targeted Disruption 16 79.72 Quite High
Metastasis 2 51.76 Quite High
Cancer 4 38.56 Quite Low
Lysosome Storage Disease 2 11.16 Low Low
Gauchers Disease 2 10.32 Low Low
Infection 12 8.24 Low Low
Cytomegalovirus Infection 12 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of MT-COMP in the absence of shRNA 3B elevates CRT levels, indicating increased ER stress (Fig. 3F).
Gene_expression (Expression) of MT-COMP Positive_regulation (elevates) of CRT associated with stress
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.57 Pain Relevance 0
Moreover, in both COS-7 and RCS cells, shRNA 3B reduced the elevated CRT levels that result from the overexpression of COMP.
Gene_expression (overexpression) of COMP Positive_regulation (result) of CRT associated with chondrosarcoma
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.41 Pain Relevance 0

General Comments

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