INT30731

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Context Info
Confidence 0.49
First Reported 1986
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 6.55
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GGT1) plasma membrane (GGT1) transferase activity, transferring acyl groups (GGT1)
cellular amino acid metabolic process (GGT1)
GGT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 3 99.52 Very High Very High Very High
depression 1 93.24 High High
addiction 11 92.12 High High
backache 3 92.00 High High
alcohol 9 91.32 High High
Sciatica 2 89.92 High High
drug abuse 4 88.56 High High
headache 5 88.16 High High
Paracetamol 5 75.44 Quite High
palliative 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Hepatomegaly 2 99.96 Very High Very High Very High
Alcohol Addiction 4 99.82 Very High Very High Very High
Disease 19 99.74 Very High Very High Very High
Abdominal Pain 3 99.52 Very High Very High Very High
Toxicity 7 98.88 Very High Very High Very High
Metastasis 12 98.84 Very High Very High Very High
Exfoliation Syndrome 69 97.96 Very High Very High Very High
Anaemia 3 97.04 Very High Very High Very High
Lymphopenia 3 96.16 Very High Very High Very High
Myalgia 6 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All orthopedic treatment administered between 1970 and 1982 was analyzed in random subsamples of men 28, 38, and 48 years old being screened for serum gamma-glutamyltransferase (GGT) levels.
Positive_regulation (screened) of Gene_expression (levels) of GGT
1) Confidence 0.49 Published 1986 Journal Prev Med Section Abstract Doc Link 2872670 Disease Relevance 0.28 Pain Relevance 0.18
Abdominal metastases were determined by abdominal pain/tension, hepatomegaly, elevated GGT levels, serum LDH levels >500 IU, a N2 or N3 case, KPS</=70, sensitivity of 95.9, specificity of 7.1, PPV of 13.3, NPV of 92.1 and SMR of 4.1%.
Spec (determined) Positive_regulation (elevated) of Gene_expression (levels) of GGT associated with abdominal pain, hepatomegaly and metastasis
2) Confidence 0.49 Published 2007 Journal Lung Cancer Section Abstract Doc Link 17566597 Disease Relevance 1.45 Pain Relevance 0.10
-glutamyl transpeptidase levels were elevated about 1.5-fold the normal limits and that aspartate aminotransferase (AST) levels were marginally elevated.
Positive_regulation (elevated) of Gene_expression (levels) of glutamyl transpeptidase
3) Confidence 0.49 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1459933 Disease Relevance 0.56 Pain Relevance 0.09
In summary, for these three SNPs, the GGT haplotype was overrepresented by 66% and constituted a major risk haplotype for XFS while the GAC haplotype was underrepresented by 83% and had the lowest associated risk in XFS patients.
Positive_regulation (overrepresented) of Gene_expression (overrepresented) of GGT associated with exfoliation syndrome
4) Confidence 0.49 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.71 Pain Relevance 0
This participant also had elevated ALP and GGT levels on Days 22, 28, 37, 55, 70, and 118, which progressively returned to normal.
Positive_regulation (elevated) of Gene_expression (levels) of GGT
5) Confidence 0.49 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 0.49 Pain Relevance 0
Treatment was interrupted for one dalcetrapib participant due to increased (>3 × ULN) levels of alkaline phosphatase (ALP), ALT, and gamma-glutamyl transferase (GGT) on Day 19.
Positive_regulation (increased) of Gene_expression (levels) of GGT
6) Confidence 0.49 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 0.58 Pain Relevance 0
Both patients had systemic progression of disease as possible explanation for the GGT elevation.
Spec (possible) Positive_regulation (explanation) of Gene_expression (elevation) of GGT associated with disease
7) Confidence 0.49 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 0.84 Pain Relevance 0.08
Particularly useful laboratory indicators of alcoholism include elevated levels of GGT and MCV, both displaying high specificity, with the GGT level being the most sensitive.
Positive_regulation (elevated) of Gene_expression (levels) of GGT associated with alcohol addiction
8) Confidence 0.45 Published 1993 Journal Prim. Care Section Abstract Doc Link 8464947 Disease Relevance 1.37 Pain Relevance 0.52
All orthopedic treatment administered between 1970 and 1982 was analyzed in random subsamples of men 28, 38, and 48 years old being screened for serum gamma-glutamyltransferase (GGT) levels.
Positive_regulation (screened) of Gene_expression (levels) of serum gamma-glutamyltransferase
9) Confidence 0.41 Published 1986 Journal Prev Med Section Abstract Doc Link 2872670 Disease Relevance 0.28 Pain Relevance 0.18

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