INT30733

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Context Info
Confidence 0.55
First Reported 1986
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.83
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Atxn2) nucleus (Atxn2) cytoplasm (Atxn2)
Anatomy Link Frequency
neurons 1
nerve 1
internal 1
Atxn2 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 6 94.12 High High
antagonist 18 79.48 Quite High
Sciatic nerve 1 75.52 Quite High
Spinal cord 4 72.32 Quite High
ischemia 9 44.12 Quite Low
Hippocampus 13 33.64 Quite Low
cerebral cortex 3 31.60 Quite Low
Central nervous system 13 5.00 Very Low Very Low Very Low
adenocard 12 5.00 Very Low Very Low Very Low
Neurotransmitter 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ataxia 33 93.12 High High
Death 7 83.88 Quite High
Injury 5 81.12 Quite High
Targeted Disruption 15 74.24 Quite High
Frailty 2 66.84 Quite High
Disease 39 60.00 Quite High
Cicatrix 1 54.08 Quite High
Syndrome 1 52.36 Quite High
Spinocerebellar Ataxia Type 2 17 48.56 Quite Low
Cv General 4 Under Development 1 44.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of SCA2, interruptions by CAA trinucleotides at the 5?
Localization (case) of SCA2
1) Confidence 0.55 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.41 Pain Relevance 0
The action of Anemonia sulcata toxin II (ATX-II) on spontaneous quantal transmitter release from motor nerve terminals was investigated by recording miniature end-plate potentials (MEPPs) from isolated mouse phrenic nerve--hemidiaphragm nerve--muscle preparations.
Localization (release) of ATX-II in nerve
2) Confidence 0.26 Published 1986 Journal Toxicon Section Abstract Doc Link 2872736 Disease Relevance 0 Pain Relevance 0
It is likely that ATX-II, by increasing intraterminal Na+ concentration, may trigger calcium release from internal stores.
Localization (release) of ATX-II in internal
3) Confidence 0.24 Published 1986 Journal Toxicon Section Abstract Doc Link 2872736 Disease Relevance 0 Pain Relevance 0.26
In addition, in this mixed model of differentiation and axotomy, the colocalization of ataxin-2 (ax-2, involved in resistance to degeneration phenomena, which may be lost after mutation)-immunopositive cells and P2X2 receptors was demonstrated in neurons, and post-lesional induction of P2X1 receptor and ax-2 immunoreactivity was reported as well [170].
Localization (colocalization) of ataxin-2 in neurons
4) Confidence 0.06 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.43 Pain Relevance 0.15

General Comments

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