INT30738

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 32
Total Number 34
Disease Relevance 19.01
Pain Relevance 5.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB)
DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)
Anatomy Link Frequency
liver 6
muscle 2
eosinophil 2
urine 2
blood 2
ALB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 89 99.98 Very High Very High Very High
methadone 12 99.98 Very High Very High Very High
Morphine 10 98.90 Very High Very High Very High
Inflammatory response 4 97.52 Very High Very High Very High
tolerance 13 95.92 Very High Very High Very High
Bile 7 95.52 Very High Very High Very High
cytokine 34 93.36 High High
headache 8 90.16 High High
analgesia 1 88.64 High High
Paracetamol 16 88.00 High High
Disease Link Frequency Relevance Heat
Albuminuria 54 100.00 Very High Very High Very High
Weight Loss 31 100.00 Very High Very High Very High
Calcification 11 100.00 Very High Very High Very High
INFLAMMATION 89 99.98 Very High Very High Very High
Hypoalbuminemia 62 99.96 Very High Very High Very High
Frailty 16 99.96 Very High Very High Very High
Cancer 283 99.84 Very High Very High Very High
Hepatotoxicity 15 99.68 Very High Very High Very High
Appetite Loss 30 99.64 Very High Very High Very High
Disease 143 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concentrations of 0.8 mM morphine and heroin, 0.4 mM meperidine, and 0.005 mM methadone inhibited the albumin synthesis by about 50% after 24 h of pretreatment.
Negative_regulation (inhibited) of Gene_expression (synthesis) of albumin associated with methadone and morphine
1) Confidence 0.59 Published 1987-1988 Journal Mol Toxicol Section Abstract Doc Link 3509697 Disease Relevance 0.16 Pain Relevance 1.21
Simultaneously, there is reduced synthesis of binding proteins, such as albumin prealbumin, and transferrin.


Negative_regulation (reduced) of Gene_expression (synthesis) of albumin
2) Confidence 0.57 Published 1999 Journal Crit Care Section Body Doc Link PMC137235 Disease Relevance 0.25 Pain Relevance 0.05
Malnutrition and inflammation suppress albumin synthesis [29].
Negative_regulation (suppress) of Gene_expression (synthesis) of albumin associated with appetite loss and inflammation
3) Confidence 0.43 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.20 Pain Relevance 0.15
In the later stages of disease, malnutrition and inflammation suppress albumin synthesis [30].
Negative_regulation (suppress) of Gene_expression (synthesis) of albumin associated with appetite loss, inflammation and disease
4) Confidence 0.43 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.19 Pain Relevance 0.21
Methadone metabolism led to decreased urea and albumin production.
Negative_regulation (decreased) of Gene_expression (production) of albumin associated with methadone
5) Confidence 0.43 Published 2010 Journal Tissue Eng Part A Section Abstract Doc Link 19778170 Disease Relevance 0.21 Pain Relevance 1.19
After stepwise logistic regression, the variables that remained in the model explaining excreted albumin in the urine of adult males were presence of leukocytes in urine (OR?
Negative_regulation (remained) of Gene_expression (explaining) of albumin in urine
6) Confidence 0.42 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2752803 Disease Relevance 0.41 Pain Relevance 0
generation ex vivo.52 Cilomilast, given 15 mg twice daily for 12 weeks, significantly reduced the numbers of subepithelial CD8+ T lymphocytes and CD68+ macrophages in bronchial biopsies in COPD patients.53 Finally, Bay 19-8004 reduced levels of albumin and eosinophil cationic protein in sputum samples obtained from patients with COPD.54

Pharmacokinetics of roflumilast and roflumilast N-oxide

Negative_regulation (reduced) of Gene_expression (levels) of albumin in eosinophil associated with pulmonary disease
7) Confidence 0.41 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915539 Disease Relevance 0.70 Pain Relevance 0.13
Bovine serum albumin (BSA), soybean trypsin inhibitor, and linoleic acid were purchased from Sigma Chemical Co., (St.
Negative_regulation (inhibitor) of Gene_expression (purchased) of serum albumin
8) Confidence 0.41 Published 2005 Journal J Autoimmune Dis Section Body Doc Link PMC1187915 Disease Relevance 0.27 Pain Relevance 0.08
A standard curve was prepared using oxidized bovine serum albumin (BSA) obtained by oxidation of BSA with Cu2+/H2O2 (500 ?
Negative_regulation (prepared) of Gene_expression (using) of serum albumin
9) Confidence 0.41 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1876613 Disease Relevance 0 Pain Relevance 0
RESULTS—When the presence of albuminuria (uAlb) was defined as urinary albumin-to-creatinine ratio (?
Negative_regulation (defined) of Gene_expression (presence) of albumin associated with albuminuria
10) Confidence 0.41 Published 2008 Journal Diabetes Care Section Abstract Doc Link PMC2518358 Disease Relevance 0.89 Pain Relevance 0
Biochemistry was within normal levels, as well as coagulation time exams, except for elevated CRP count (at 45 mg/L) and decreased Albumin/Globulin ratio.
Neg (except) Negative_regulation (decreased) of Gene_expression (ratio) of Albumin
11) Confidence 0.41 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2933587 Disease Relevance 0.71 Pain Relevance 0.13
Microalbuminuria was defined as a urinary albumin excretion between 20 and 200 ?
Negative_regulation (defined) of Gene_expression (excretion) of albumin
12) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621377 Disease Relevance 1.17 Pain Relevance 0
An early culture phase (3 days after isolation) could be described with decreasing DNA content of the cultures, peak values of alanine-amino-transferase (ALAT), and increasing albumin synthesis.
Negative_regulation (decreasing) of Gene_expression (synthesis) of albumin
13) Confidence 0.38 Published 1994 Journal Xenobiotica Section Abstract Doc Link 8017092 Disease Relevance 0 Pain Relevance 0.24
At low albumin concentrations, the transfer of lopinavir and ritonavir was compatible with passive diffusion, whereas the clearance decreased significantly at physiological albumin concentrations (30 and 40?
Negative_regulation (decreased) of Gene_expression (concentrations) of albumin
14) Confidence 0.37 Published 2009 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2778444 Disease Relevance 0.22 Pain Relevance 0
These spheroids exhibited higher amounts of albumin and urea synthesis than the control monolayer culture.
Negative_regulation (amounts) of Gene_expression (synthesis) of albumin
15) Confidence 0.33 Published 2009 Journal Journal of tissue engineering and regenerative medicine Section Abstract Doc Link 19408239 Disease Relevance 0 Pain Relevance 0.09
before analysis precludes the detection of albumin–toxin
Negative_regulation (precludes) of Gene_expression (detection) of albumin
16) Confidence 0.29 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1552036 Disease Relevance 0 Pain Relevance 0
The trial achieved a 60% reduction in mean serum aflatoxin–albumin levels in people in intervention villages.
Negative_regulation (reduction) of Gene_expression (levels) of albumin
17) Confidence 0.27 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1764136 Disease Relevance 0.24 Pain Relevance 0.03
The trial achieved a 60% reduction in mean serum aflatoxin–albumin levels in people in intervention villages.
Negative_regulation (reduction) of Gene_expression (levels) of serum aflatoxin
18) Confidence 0.23 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1764136 Disease Relevance 0.24 Pain Relevance 0.03
In addition, there was a trend for slight decreases in hemoglobin, hematocrit, white blood cell count, total protein, and albumin levels in those patients who received terazosin, suggesting hemodilution.
Negative_regulation (decreases) of Gene_expression (levels) of albumin in white blood cell
19) Confidence 0.20 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 2872812 Disease Relevance 0.55 Pain Relevance 0.17
Albumin synthesis and expression of liver-enriched genes were confirmed, but gradually decreased as passages progressed.
Negative_regulation (decreased) of Gene_expression (synthesis) of Albumin in liver
20) Confidence 0.18 Published 2008 Journal Cell Transplant Section Abstract Doc Link 19177844 Disease Relevance 0.62 Pain Relevance 0.07

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