INT307453

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.16
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsk3a) signal transduction (Gsk3a) extracellular region (Bdnf)
cytoplasmic membrane-bounded vesicle (Bdnf) carbohydrate metabolic process (Gsk3a)
Anatomy Link Frequency
neurons 2
Bdnf (Rattus norvegicus)
Gsk3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 21 96.40 Very High Very High Very High
Glutamate 15 72.00 Quite High
antagonist 12 65.52 Quite High
nMDA receptor 9 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 18 88.16 High High
Apoptosis 39 71.32 Quite High
Pain 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of NMDA and BzATP the increase percentages in GSK3 phosphorylation were in the same range, being always slightly higher for NMDA.Fig. 1GSK3 phosphorylation induced by BzATP, NMDA and BDNF in granule neurons. a Time-course of GSK3 phosphorylation.
BDNF Positive_regulation (induced) of Phosphorylation (phosphorylation) of 1GSK3 in neurons
1) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.10
Pre-treatment with the MAPK inhibitor, U-0126, was also able to diminish BDNF-induced recovery in the levels of GSK3 phosphorylation (Fig. 5c).
BDNF Positive_regulation (induced) of Phosphorylation (phosphorylation) of GSK3
2) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.07 Pain Relevance 0
BDNF was the most potent at inducing GSK3 phosphorylation, which was also dependent on PI3K.
BDNF Positive_regulation (inducing) of Phosphorylation (phosphorylation) of GSK3
3) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Abstract Doc Link PMC2858808 Disease Relevance 0.09 Pain Relevance 0.08

General Comments

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