INT307454

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.13 Pain Relevance 0.05

cytosol (Prkcg, Gsk3a) signal transduction (Gsk3a) plasma membrane (Prkcg) nucleus (Prkcg) intracellular (Prkcg) carbohydrate metabolic process (Gsk3a)

Prkcg (Rattus norvegicus) Gsk3a (Rattus norvegicus)

Pain Link Frequency Relevance Heat nMDA receptor 3 97.44 Glutamate 5 23.08 agonist 7 5.00 antagonist 4 5.00 withdrawal 2 5.00 addiction 2 5.00 Spinal cord 1 5.00 Inflammation 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 13 81.96 Death 6 5.00 Pain 1 5.00 Neurodegenerative Disease 1 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The different approaches used revealed that calcium-dependent PKC isoforms were responsible for the GSK3 phosphorylation and the neuroprotective effects displayed by the three effectors, which could corresponded to PKC?

PKC Regulation (responsible) of Phosphorylation (phosphorylation) of GSK3

1) Confidence 0.04 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.13 Pain Relevance 0.05

General Comments

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