INT307455

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsk3a) signal transduction (Gsk3a) extracellular region (Bdnf)
cytoplasmic membrane-bounded vesicle (Bdnf) carbohydrate metabolic process (Gsk3a)
Anatomy Link Frequency
neurons 1
Gsk3a (Rattus norvegicus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 5 74.56 Quite High
nMDA receptor 3 16.88 Low Low
agonist 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 13 87.76 High High
Death 6 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, our data provide evidence that GSK3 is an important and generalized signalling target for different unrelated physiologically relevant stimuli in granule neurons including trophic factors, such as BDNF, to rapidly diffusible extracellular signals, such as ATP.
GSK3 Regulation (target) of BDNF in neurons
1) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.09 Pain Relevance 0.04

General Comments

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