INT307457

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pik3cb, Gsk3a) signal transduction (Pik3cb, Gsk3a) cell adhesion (Pik3cb)
nucleus (Pik3cb) carbohydrate metabolic process (Gsk3a) cytoplasm (Pik3cb)
Pik3cb (Rattus norvegicus)
Gsk3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 7 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 13 79.36 Quite High
Death 6 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 5 show that pre-treatment with the PKC inhibitor Gö 6976 did not alter the loss in GSK3 phosphorylation levels induced by the PI3K inhibitor, but totally prevented the recovery mediated by BzATP, NMDA and BDNF.
Negative_regulation (inhibitor) of PI3K Positive_regulation (induced) of GSK3
1) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.08 Pain Relevance 0

General Comments

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