INT307459

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) extracellular region (Bdnf)
cytoplasmic membrane-bounded vesicle (Bdnf) plasma membrane (P2rx4)
Anatomy Link Frequency
spinal cord neurons 2
P2rx4 (Rattus norvegicus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 1 99.84 Very High Very High Very High
Pain 1 98.40 Very High Very High Very High
Inflammation 1 48.72 Quite Low
Glutamate 5 45.24 Quite Low
agonist 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 1 98.40 Very High Very High Very High
INFLAMMATION 1 48.72 Quite Low
Neurodegenerative Disease 1 47.36 Quite Low
Apoptosis 13 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In activated microglia, P2X4 is up-regulated and promotes BDNF release in spinal cord neurons contributing to pain signalling [33].
P2X4 Positive_regulation (promotes) of Localization (release) of BDNF in spinal cord neurons associated with pain and spinal cord
1) Confidence 0.15 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.10 Pain Relevance 0.15

General Comments

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