INT307460

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) carbohydrate metabolic process (Gsk3a) protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)

Anatomy Link Frequency neurons 2 P2rx7 (Rattus norvegicus) Gsk3a (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate 5 44.24 agonist 7 5.00 antagonist 4 5.00 nMDA receptor 3 5.00 withdrawal 2 5.00 addiction 2 5.00 Spinal cord 1 5.00 Inflammation 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 13 17.84 Death 6 5.00 Pain 1 5.00 Neurodegenerative Disease 1 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

P2X7, NMDA and TrkB receptors trigger different intracellular pathways to induce GSK3 phosphorylation and elicit neuroprotection in granule neurons.

P2X7 Positive_regulation (induce) of Phosphorylation (phosphorylation) of GSK3 in neurons

1) Confidence 0.02 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0

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