INT307464
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In a previous work, the effect of several nucleotidic agonists on GSK3 phosphorylation was investigated, and among them, BzATP resulted to be the most potent, through the activation of the P2X7 nucleotide receptor. | |||||||||||||||
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The different approaches used revealed that calcium-dependent PKC isoforms were responsible for the GSK3 phosphorylation and the neuroprotective effects displayed by the three effectors, which could corresponded to PKC? | |||||||||||||||
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From the present results it is clear that the full effect of NMDA-receptor activation on GSK3 phosphorylation is obtained primarily through a PKC-dependent pathway, in the same way that BzATP acting through P2X7 receptors. | |||||||||||||||
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Recent studies have further investigated the intracellular signalling mechanisms triggered by nucleotide receptors and have demonstrated the coupling of P2Y13 and P2X7 receptors to GSK3 phosphorylation in rat cerebellar granule neurons. | |||||||||||||||
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P2X7 and NMDA receptors converge on GSK3 phosphorylation in granule neurons | |||||||||||||||
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In addition, MAPKs were also involved in the survival signalling mechanism triggered by BDNF (Fig. 6).Fig. 5Effect of PKC and MAPK inhibition on GSK3 phosphorylation levels under conditions of PI3K inhibition. | |||||||||||||||
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Figure 5 show that pre-treatment with the PKC inhibitor Gö 6976 did not alter the loss in GSK3 phosphorylation levels induced by the PI3K inhibitor, but totally prevented the recovery mediated by BzATP, NMDA and BDNF. | |||||||||||||||
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