INT307469

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.12
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsk3a) signal transduction (Gsk3a) carbohydrate metabolic process (Gsk3a)
Anatomy Link Frequency
neurons 1
Gsk3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 22 93.92 High High
carbamazepine 18 93.12 High High
Raphe 2 86.92 High High
withdrawal 6 86.80 High High
antidepressant 2 86.64 High High
Serotonin 6 84.72 Quite High
addiction 6 82.24 Quite High
antagonist 14 76.68 Quite High
Glutamate 23 74.56 Quite High
bDMF 32 65.72 Quite High
Disease Link Frequency Relevance Heat
Shock 2 94.52 High High
Depression 28 93.92 High High
Death 20 88.80 High High
Neurodegenerative Disease 11 87.96 High High
Apoptosis 47 87.76 High High
Manic Depressive Disorder 250 5.00 Very Low Very Low Very Low
Recurrence 16 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 12 5.00 Very Low Very Low Very Low
Psychosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The coupling of BzATP, NMDA and BDNF to GSK3 regulation led us to investigate the physiological meaning of this signalling mechanism.
Regulation (regulation) of GSK3
1) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.17 Pain Relevance 0.08
Therefore, our data provide evidence that GSK3 is an important and generalized signalling target for different unrelated physiologically relevant stimuli in granule neurons including trophic factors, such as BDNF, to rapidly diffusible extracellular signals, such as ATP.
Regulation (target) of GSK3 in neurons
2) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.09 Pain Relevance 0.04
Finally, we assessed the role of the MAPK pathway in GSK3 regulation using U-0126 (10 ?
Regulation (regulation) of GSK3
3) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.07
As we mentioned earlier, the Wnt signalling pathway converges on GSK-3?.
Regulation (converges) of GSK-3
4) Confidence 0.04 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.41 Pain Relevance 0.29
It has been shown that the serotonergic pathway is a downstream target of GSK-3?
Regulation (target) of GSK-3
5) Confidence 0.03 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.45 Pain Relevance 0.35

General Comments

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