INT307472

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.83
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsk3a) signal transduction (Gsk3a) carbohydrate metabolic process (Gsk3a)
Gsk3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 32 94.64 High High
carbamazepine 18 88.16 High High
Neurotransmitter 4 87.76 High High
depression 22 66.80 Quite High
antidepressant 2 59.52 Quite High
Serotonin 6 50.64 Quite High
Raphe 2 45.92 Quite Low
Lamotrigine 46 5.00 Very Low Very Low Very Low
anticonvulsant 16 5.00 Very Low Very Low Very Low
Gabapentin 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 9 99.20 Very High Very High Very High
Shock 2 85.76 High High
Apoptosis 21 80.08 Quite High
Depression 28 66.80 Quite High
Manic Depressive Disorder 250 5.00 Very Low Very Low Very Low
Recurrence 16 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 12 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Psychosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 5 show that pre-treatment with the PKC inhibitor Gö 6976 did not alter the loss in GSK3 phosphorylation levels induced by the PI3K inhibitor, but totally prevented the recovery mediated by BzATP, NMDA and BDNF.
Regulation (alter) of Negative_regulation (loss) of GSK3
1) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.08 Pain Relevance 0
In this regard, it has been shown that alternative inhibitors of GSK-3?
Regulation (alternative) of Negative_regulation (inhibitors) of GSK-3
2) Confidence 0.04 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.47 Pain Relevance 0.28
It has been reported that lithium inhibition of GSK-3?
Regulation (reported) of Negative_regulation (inhibition) of GSK-3
3) Confidence 0.04 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.28 Pain Relevance 0.17

General Comments

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