INT3076

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Context Info
Confidence 0.60
First Reported 1978
Last Reported 2010
Negated 9
Speculated 4
Reported most in Abstract
Documents 52
Total Number 57
Disease Relevance 20.39
Pain Relevance 27.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
Anatomy Link Frequency
smooth muscle 2
brain 2
muscle 2
urine 2
nerve 2
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 382 100.00 Very High Very High Very High
Inflammation 140 100.00 Very High Very High Very High
agonist 77 100.00 Very High Very High Very High
Pain 54 100.00 Very High Very High Very High
antagonist 41 100.00 Very High Very High Very High
Kinase C 34 100.00 Very High Very High Very High
substance P 28 100.00 Very High Very High Very High
cytokine 28 100.00 Very High Very High Very High
Serotonin 26 100.00 Very High Very High Very High
qutenza 26 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hereditary Angioedema 144 100.00 Very High Very High Very High
INFLAMMATION 143 100.00 Very High Very High Very High
Pain 32 100.00 Very High Very High Very High
Hyperalgesia 25 100.00 Very High Very High Very High
Natriuresis 1 100.00 Very High Very High Very High
Nociception 5 99.78 Very High Very High Very High
Pressure And Volume Under Development 140 99.66 Very High Very High Very High
Increased Venous Pressure Under Development 175 99.56 Very High Very High Very High
Asthma 62 98.36 Very High Very High Very High
Ganglion Cysts 12 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Autoregulation of bradykinin receptors: agonists in the presence of interleukin-1beta shift the repertoire of receptor subtypes from B2 to B1 in human lung fibroblasts.
Regulation (Autoregulation) of bradykinin in lung associated with agonist and bradykinin
1) Confidence 0.60 Published 1999 Journal Mol. Pharmacol. Section Title Doc Link 10419551 Disease Relevance 0.25 Pain Relevance 0.75
Regulation of bradykinin sensitivity in peripheral sensory fibres of the neonatal rat by nitric oxide and cyclic GMP.
Regulation (Regulation) of bradykinin associated with nociceptor and bradykinin
2) Confidence 0.46 Published 1994 Journal Neuropharmacology Section Title Doc Link 7862249 Disease Relevance 0 Pain Relevance 0.71
OBJECTIVES: This study assessed the algesic activity of bradykinin (BK) in humans and the effects of acetylsalicylate on muscular and cardiac BK-induced pain.
Regulation (effects) of bradykinin associated with pain and bradykinin
3) Confidence 0.45 Published 1999 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 10400014 Disease Relevance 0.17 Pain Relevance 0.36
The pain and hyperalgesia to heat following bradykinin was found to be unaffected by the sympathectomy.
Neg (unaffected) Regulation (unaffected) of bradykinin associated with pain, hyperalgesia and bradykinin
4) Confidence 0.45 Published 1992 Journal Pain Section Abstract Doc Link 1491860 Disease Relevance 0.84 Pain Relevance 1.14
The aim of this study was to investigate the effects of local anaesthetics on the cutaneous flare responses to bradykinin and substance P.
Spec (investigate) Regulation (effects) of bradykinin associated with bradykinin and substance p
5) Confidence 0.45 Published 2008 Journal Anaesthesia Section Abstract Doc Link 18211446 Disease Relevance 0.19 Pain Relevance 0.79
To determine whether the ductus arteriosus can form endothelium-derived relaxing factor--nitric oxide, we used isolated ductal strips from near-term fetal lamb and examined their response to bradykinin (a nitric oxide stimulator), L-arginine (a nitric oxide precursor), and agents interfering with the synthesis (N omega-nitro-L-arginine) and action (methylene blue) of nitric oxide.
Spec (examined) Regulation (response) of bradykinin in ductus arteriosus associated with bradykinin
6) Confidence 0.44 Published 1994 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8012902 Disease Relevance 0 Pain Relevance 0.13
Neither the saline volume control nor bradykinin nor capsaicin injected subfascially or intramuscularly affected the response of L6 multifidus muscle spindles to ramp and hold vertebral loads in the alpha-chloralose-anesthetized cat.
Neg (Neither) Regulation (control) of bradykinin in muscle
7) Confidence 0.44 Published 2001 Journal Spine Section Body Doc Link 11462081 Disease Relevance 0 Pain Relevance 0
Sensitizing effects of bradykinin on the heat responses of the visceral nociceptor.
Regulation (effects) of bradykinin in visceral associated with analgesic, nociceptor and bradykinin
8) Confidence 0.44 Published 1991 Journal J. Neurophysiol. Section Title Doc Link 1667414 Disease Relevance 0.10 Pain Relevance 1.21
We have therefore investigated the effect of prostaglandin E2 (PGE2), bradykinin (BK), histamine (H), and citric acid (C) on capsaicin-induced cough and increase in respiratory resistance (Rrs).
Spec (investigated) Regulation (effect) of bradykinin in respiratory associated with qutenza, cough and bradykinin
9) Confidence 0.41 Published 1989 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 2751160 Disease Relevance 0.81 Pain Relevance 0.76
Immunoblot assays for detection of changes in the structure of HMWK and prekallikrein may be objective laboratory studies for documenting clinical attacks of hereditary angioedema, their onset, and their resolution.
Regulation (changes) of HMWK associated with hereditary angioedema
10) Confidence 0.41 Published 1990 Journal J. Lab. Clin. Med. Section Abstract Doc Link 1688910 Disease Relevance 0.24 Pain Relevance 0
Our results demonstrate that bradykinin formation is controlled by HK binding to and detachment from GAGs.
Regulation (controlled) of bradykinin associated with bradykinin
11) Confidence 0.41 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16116231 Disease Relevance 0.26 Pain Relevance 0.52
The actions of bradykinin were not affected after B1-bradykinin receptors were blocked with des-Arg9-[Leu8]bradykinin.
Neg (not) Regulation (affected) of bradykinin associated with bradykinin
12) Confidence 0.38 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3215268 Disease Relevance 0 Pain Relevance 0.40
By this means, fragments arising from HK processing propagate bradykinin generation, revealing a novel regulatory level for the kallikrein-kinin system.
Regulation (propagate) of bradykinin associated with bradykinin
13) Confidence 0.36 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16116231 Disease Relevance 0.09 Pain Relevance 0.38
Bradykinin is a mediator of inflammation, responsible for pain, vasodilation, and capillary permeability.
Regulation (responsible) of Bradykinin in capillary associated with pain, inflammation, increased venous pressure under development and bradykinin
14) Confidence 0.35 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15805101 Disease Relevance 0.89 Pain Relevance 0.54
Effects of three alpha 2-adrenoceptor agonists, rilmenidine, UK 14304 and clonidine on bradykinin- and substance P-induced airway microvascular leakage in guinea-pigs.
Regulation (Effects) of bradykinin associated with agonist, bradykinin, substance p and clonidine
15) Confidence 0.35 Published 1995 Journal Neuropeptides Section Title Doc Link 7541119 Disease Relevance 0 Pain Relevance 0.76
BDK activity is regulated by alpha-ketoisocaproate inhibition and altered level of expression.
Regulation (regulated) of BDK
16) Confidence 0.29 Published 2005 Journal J. Nutr. Section Abstract Doc Link 15930464 Disease Relevance 0.21 Pain Relevance 0.11
The effect of bradykinin was studied by inhalation in normal and asthmatic human subjects, as well as on human bronchial smooth muscle in vitro.
Regulation (effect) of bradykinin in smooth muscle associated with asthma and bradykinin
17) Confidence 0.27 Published 1987 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3541715 Disease Relevance 0.27 Pain Relevance 0.36
Further confirmation of the altered levels of CD59, kininogen-1 and fragments of ITIH4 and albumin in the urine of patients with ovarian carcinoma relative to those of the control subjects was performed using antibodies and a lectin that bind to the respective proteins that were blotted onto membranes.
Regulation (altered) of kininogen-1 in urine associated with ovarian cancer
18) Confidence 0.26 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.47 Pain Relevance 0
However, the effects of ACEI are dose-related (Campbell et al 1994), and studies in man showed that although perindoprilat is more lipophilic, with more rapid and efficient myocardial uptake than enalaprilat, the two ACEI produced similar changes in angiotensin and bradykinin peptide levels in arterial and coronary sinus blood of humans with CHD (Zeitz et al 2003).


Regulation (changes) of bradykinin in blood associated with coronary artery disease and bradykinin
19) Confidence 0.26 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993997 Disease Relevance 0.43 Pain Relevance 0.05
The aim of the present study was to investigate if increased intramuscular concentrations of bradykinin (BK) in one muscle influence the activity in primary and secondary muscle spindle afferents (MSAs) originating from both ipsi- and contralateral muscles, via fusimotor reflexes.
Regulation (influence) of bradykinin in muscle associated with bradykinin
20) Confidence 0.26 Published 1997 Journal Pain Section Abstract Doc Link 9106812 Disease Relevance 0.05 Pain Relevance 0.20

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