INT307635

Context Info Confidence 0.38 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.35 Pain Relevance 0.36

cell differentiation (BMP1) peptidase activity (BMP1) extracellular space (BMP1) small molecule metabolic process (BMP1) extracellular region (BMP1) lipid metabolic process (BMP1)

Anatomy Link Frequency small intestine 2 urine 2 BMP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Dextromethorphan 2 90.64 withdrawal 2 74.16 cocaine 4 71.40 Central nervous system 6 68.32 anesthesia 10 62.72 analgesia 6 61.52 alcohol 4 57.28 Hippocampus 2 53.68 Limbic system 2 50.24 Onset of action 2 41.40

Disease Link Frequency Relevance Heat Poisoning 42 96.40 Obesity 2 83.72 Overdose 4 70.96 Neuroleptic Malignant Syndrome 2 68.80 Thyroid Crisis 2 67.36 Viral Meningitis 2 66.76 Meningitis 2 66.08 Sepsis 2 65.60 Hyponatremia 2 65.28 Hypoglycemia 4 64.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The simplest way to confirm suspected PCP intoxication is via qualitative chromatographic or immunologic urine drug screen, since 9% of the active drug is excreted directly by the kidneys.11 The urine is usually positive for 2–4 days after PCP use, but after chronic exposure the test results can be positive for over a week.34

Positive_regulation (after) of Localization (use) of PCP in urine associated with poisoning

1) Confidence 0.38 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 1.14 Pain Relevance 0.12

Regardless of the method of administration, significant amounts of the weakly basic PCP are actively secreted into the acid milieu of the stomach, accumulating to levels up to 50 times higher than serum levels, where it is then reabsorbed in the small intestine.

Positive_regulation (accumulating) of Localization (secreted) of PCP in small intestine

2) Confidence 0.38 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859735 Disease Relevance 0.21 Pain Relevance 0.24

General Comments

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