INT307721

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Context Info
Confidence 0.76
First Reported 2010
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 1
Total Number 50
Disease Relevance 45.01
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (PALLD) nucleus (PALLD) cytoskeleton organization (PALLD)
cytoplasm (PALLD)
Anatomy Link Frequency
pancreas 11
fibroblasts 6
epithelial cells 3
stroma 2
band 2
PALLD (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 50 99.32 Very High Very High Very High
Chronic pancreatitis 100 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adenocarcinoma 2200 100.00 Very High Very High Very High
Cancer 4350 99.96 Very High Very High Very High
Pancreatic Cancer 1050 99.92 Very High Very High Very High
Congenital Anomalies 50 99.92 Very High Very High Very High
Disease Progression 100 99.68 Very High Very High Very High
Confusion 50 99.60 Very High Very High Very High
Breast Cancer 300 99.54 Very High Very High Very High
Fibrosis 150 99.32 Very High Very High Very High
Metastasis 800 99.14 Very High Very High Very High
Metaplasia 50 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two previous studies have explored palladin expression in cultured cells derived from pancreas tumors, and both focused on the widely-expressed 85–90 kDa palladin isoform [5], [6], yet these previous studies also presented evidence that pancreatic tumor-derived cell types express smaller, uncharacterized palladin variants (see, for example, the 75 kDa band in Fig. 2 of reference 6).
Gene_expression (expression) of palladin in band associated with cancer and pancreatic cancer
1) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.31 Pain Relevance 0
In this study, we analyzed the expression of palladin isoforms in murine and human PDA and explored palladin's potential use in diagnosing PDA.
Spec (analyzed) Gene_expression (expression) of palladin associated with adenocarcinoma
2) Confidence 0.76 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2859948 Disease Relevance 0.98 Pain Relevance 0
This rich diversity of isoforms raises the possibility that human cells may express palladin variants that are not detected by all antibodies, which could be the cause of previous conflicting results.
Gene_expression (express) of palladin
3) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.88 Pain Relevance 0
Although the follow-up study confirmed that palladin is overexpressed in 96% of pancreas tumors as compared to normal pancreas, it showed that palladin is upregulated in stromal fibroblasts rather than in the neoplastic cells of pancreas tumors [6].
Gene_expression (overexpressed) of palladin in pancreas associated with cancer
4) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.14 Pain Relevance 0
We performed immunohistochemical analyses on primary tumors and metastases harvested from these mice to characterize palladin expression during disease progression.
Gene_expression (expression) of palladin associated with cancer, disease progression and metastasis
5) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.34 Pain Relevance 0.03
Thus, to determine if differences in palladin expression could be detected using smaller samples, we also analyzed specimens collected from donated post-surgical organs using 18-gauge needles.
Gene_expression (expression) of palladin
6) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.66 Pain Relevance 0
Interestingly, palladin expression in the reactive fibrosis associated with acinar-ductal metaplasia regions (around the so-called “reactive ducts”) was even more robust (Figure 5).
Gene_expression (expression) of palladin in ducts associated with fibrosis and metaplasia
7) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.09 Pain Relevance 0.05
We note that the ductal epithelial cells in the adjacent PanINs do not show palladin expression, nor do the surrounding normal acinar parenchymal cells.
Gene_expression (expression) of palladin in parenchymal cells
8) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.23 Pain Relevance 0.05
To resolve the existing confusion about the level of palladin expression in different types of tumor-derived cells, we used both the broadly-reactive polyclonal antibody 622 and the isoform-selective monoclonal 1E6 to compare the pattern of isoforms detected in tumor-associated fibroblasts and neoplastic tumor cell lines.
Gene_expression (expression) of palladin in fibroblasts associated with cancer and confusion
9) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.91 Pain Relevance 0
Thus, the results provide evidence that palladin is overexpressed specifically in pancreas tumors, yet the identity of the cell type that is responsible for upregulating palladin in these tumors remains unclear.
Gene_expression (overexpressed) of palladin in pancreas associated with cancer
10) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.04 Pain Relevance 0
-SMA co-localized, which supports the conclusion that palladin is expressed in stromal cells expressing ?
Gene_expression (expressed) of palladin in stromal cells
11) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.40 Pain Relevance 0.06
Palladin-expressing fibroblasts increase in number and staining intensity with disease progression, as strongly positive TAFs were seen diffusely infiltrating the invasive ductal adenocarcinomas, along with occasional faint cytoplasmic staining of the primary tumor cells (Figure 5).
Gene_expression (expressing) of Palladin in fibroblasts associated with adenocarcinoma, cancer and disease progression
12) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.22 Pain Relevance 0.04
Neither previous study investigated palladin expression in bulk tumor samples, which contain a complex mixture of different cell types.
Spec (investigated) Gene_expression (expression) of palladin associated with cancer
13) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.81 Pain Relevance 0
Also, our results are in good agreement with a previous analysis of palladin expression that was achieved by staining of a tumor microarray, in which palladin was found to be overexpressed in >96% of pancreatic adenocarcinomas [6].
Gene_expression (overexpressed) of palladin associated with adenocarcinoma and cancer
14) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.85 Pain Relevance 0
Also, our results are in good agreement with a previous analysis of palladin expression that was achieved by staining of a tumor microarray, in which palladin was found to be overexpressed in >96% of pancreatic adenocarcinomas [6].
Gene_expression (expression) of palladin associated with adenocarcinoma and cancer
15) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.80 Pain Relevance 0
The propensity for early invasion and metastasis is a characteristic trait of pancreas tumors, such that we were prompted to explore palladin expression in samples of pancreatic cancer metastases to lymph nodes and liver to determine if palladin is upregulated in the tumor cells or the TAFs in these samples.
Gene_expression (expression) of palladin in lymph nodes associated with cancer, pancreatic cancer and metastasis
16) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.38 Pain Relevance 0
The polyclonal antibody 622 detected a single 65 kDa isoform in HPDE cells and all three tumor cell lines, and the expression level of this palladin isoform did not appear to vary significantly between normal and tumor cells.
Gene_expression (expression) of palladin isoform associated with cancer
17) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.97 Pain Relevance 0
Palladin was found to be overexpressed in samples of sporadic pancreatic adenocarcinoma and in tumor-derived cell lines [5].
Gene_expression (overexpressed) of Palladin associated with adenocarcinoma and cancer
18) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.18 Pain Relevance 0
In tumor-derived cultured cells, expression of palladin isoforms follows cell-type specific patterns, with the 85–90 kDa isoform in TAFs, and the 65 kDa isoform predominating in normal and neoplastic epithelial cells.
Gene_expression (expression) of palladin in TAFs associated with cancer
19) Confidence 0.76 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2859948 Disease Relevance 0.81 Pain Relevance 0
Therefore, we went on to determine which palladin isoforms are expressed in pancreas, and if these palladin isoforms follow cell-type specific patterns of expression in pancreatic cells.
Gene_expression (expressed) of palladin in pancreas
20) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.21 Pain Relevance 0

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