INT30777

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Context Info
Confidence 0.56
First Reported 1986
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 18.05
Pain Relevance 7.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SELL) plasma membrane (SELL)
Anatomy Link Frequency
leukocytes 5
neutrophils 3
caudate nucleus 1
internal 1
external 1
SELL (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
metalloproteinase 3 100.00 Very High Very High Very High
Enkephalin 8 99.78 Very High Very High Very High
rheumatoid arthritis 97 98.28 Very High Very High Very High
Substantia nigra 4 98.00 Very High Very High Very High
lidocaine 10 97.90 Very High Very High Very High
local anesthetic 4 97.70 Very High Very High Very High
Angina 29 96.76 Very High Very High Very High
Inflammation 231 95.84 Very High Very High Very High
agonist 5 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 312 100.00 Very High Very High Very High
Disease 169 99.84 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 44 99.20 Very High Very High Very High
Rheumatoid Arthritis 109 98.28 Very High Very High Very High
Nicotine Addiction 372 97.72 Very High Very High Very High
Cv General 3 Under Development 25 96.76 Very High Very High Very High
Atherosclerosis 29 96.48 Very High Very High Very High
INFLAMMATION 293 95.84 Very High Very High Very High
Stable Angina Pectoris 6 94.76 High High
Coronary Artery Disease 14 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cationic local anesthetic lidocaine inhibited not only FMLP-induced O2- release in neutrophils but also FMLP-induced CD11b upregulation and LAM-1 downregulation on neutrophils in a dose-dependent manner.
Negative_regulation (downregulation) of LAM-1 in neutrophils associated with lidocaine and local anesthetic
1) Confidence 0.56 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.24 Pain Relevance 0.67
Lidocaine also abolished the priming effect of rhG-CSF for enhanced release of O2- in neutrophils and inhibited rhG-CSF-induced CD11b upregulation and LAM-1 downregulation on neutrophils in a dose-dependent manner.
Negative_regulation (downregulation) of LAM-1 in neutrophils associated with lidocaine
2) Confidence 0.56 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.24 Pain Relevance 0.71
Our data show a more significant reduction of CD62L on neutrophils and monocytes following upper limb surgery which involved the use of a tourniquet.
Negative_regulation (reduction) of CD62L in monocytes
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.72 Pain Relevance 0.07
Levels of Met-enkephalin-Arg6-Gly7-Leu8 were reduced in HD caudate nucleus, putamen, internal and external globus pallidus.
Negative_regulation (reduced) of Leu8 in internal associated with enkephalin and disease
4) Confidence 0.42 Published 1986 Journal Brain Res. Section Abstract Doc Link 2873872 Disease Relevance 0.46 Pain Relevance 0.49
For instance, elevated sE-selectin and sICAM-1 have been shown to activate leukocytes following neurological insult [24], whereas high sL-selectin levels are closely associated with decreased cellular interactions and reduced microvascular damage in critically injured patients [79].
Negative_regulation (reduced) of sL-selectin in leukocytes
5) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.93 Pain Relevance 0.03
We did not observe any significant changes in the

adhesion molecules on granulocytes, but only a tendency to a decrease in CD62L levels 2 h after the start of CVVHD.

Negative_regulation (decrease) of CD62L in granulocytes associated with adhesions
6) Confidence 0.28 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 0.82 Pain Relevance 0
However, a recent comparison of adhesion molecule expression profiles on leukocyte (L-selectin, VLA-4, and the three ?
Negative_regulation (comparison) of L-selectin in leukocyte associated with adhesions
7) Confidence 0.27 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 2.18 Pain Relevance 0
However, a recent comparison of adhesion molecule expression profiles on leukocyte (L-selectin, VLA-4, and the three ?
Negative_regulation (comparison) of L-selectin in leukocyte associated with adhesions
8) Confidence 0.27 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.18 Pain Relevance 0
Similarly, increased expression of MHC II, CD86, and CD69 molecules, but decreased CD62L levels, have also been observed in activated eosinophils after in vitro exposure to Strongyloides stercolaris antigens in a murine model [47].
Negative_regulation (decreased) of CD62L in CD86
9) Confidence 0.22 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.43 Pain Relevance 0
The elevated expression of antigen-presenting and co-stimulatory molecules, but reduced levels of CD62L, indicate a highly activated state for these eosinophils.
Negative_regulation (reduced) of CD62L in eosinophils
10) Confidence 0.22 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.39 Pain Relevance 0
The antibody array plasma profiling identified an SJIA plasma flare signature consisting of tissue inhibitor of metalloproteinase-1 (TIMP1), interleukin (IL)-18, regulated upon activation, normal T cell expressed and secreted (RANTES), P-Selectin, MMP9, and L-Selectin.


Negative_regulation (inhibitor) of L-Selectin in T cell associated with metalloproteinase
11) Confidence 0.16 Published 2010 Journal Clin Proteomics Section Abstract Doc Link PMC2970804 Disease Relevance 0.91 Pain Relevance 0.21
Our data show a more significant reduction of CD62L on neutrophils and monocytes following upper limb surgery which involved the use of a tourniquet.
Negative_regulation (reduction) of CD62L in neutrophils
12) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.72 Pain Relevance 0.07
Levels of Met-enkephalin-Arg6-Gly7-Leu8 were reduced in HD caudate nucleus, putamen, internal and external globus pallidus.
Negative_regulation (reduced) of Leu8 in external associated with enkephalin and disease
13) Confidence 0.14 Published 1986 Journal Brain Res. Section Abstract Doc Link 2873872 Disease Relevance 0.46 Pain Relevance 0.49
Levels of Met-enkephalin-Arg6-Gly7-Leu8 were reduced in HD caudate nucleus, putamen, internal and external globus pallidus.
Negative_regulation (reduced) of Leu8 in caudate nucleus associated with enkephalin and disease
14) Confidence 0.14 Published 1986 Journal Brain Res. Section Abstract Doc Link 2873872 Disease Relevance 0.46 Pain Relevance 0.49
Levels of Met-enkephalin-Arg6-Gly7-Leu8 were reduced in HD caudate nucleus, putamen, internal and external globus pallidus.
Negative_regulation (reduced) of Leu8 in putamen associated with enkephalin and disease
15) Confidence 0.14 Published 1986 Journal Brain Res. Section Abstract Doc Link 2873872 Disease Relevance 0.46 Pain Relevance 0.49
To examine the mechanism of reduction in sL-selectin levels and L-selectin expression on leukocytes, leukocytes from the control group were stimulated in vitro.
Spec (examine) Negative_regulation (reduction) of sL-selectin in leukocytes
16) Confidence 0.04 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.41 Pain Relevance 0.76
Superfusion of the epicardium with a selective B1-receptor antagonist, des-Arg9-[Leu8]BK (50-100 micrograms/min) had no effect on reflex responses to epicardial BK (0.03-0.1 microgram).
Negative_regulation (antagonist) of Leu8 in epicardium associated with antagonist
17) Confidence 0.03 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2905666 Disease Relevance 0.09 Pain Relevance 0.45
A variety of cell adhesion molecules such as CD2, LFA-1, and VLA-4 are also activated while L-selectin is downregulated.
Negative_regulation (downregulated) of L-selectin associated with adhesions
18) Confidence 0.02 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.63 Pain Relevance 0.27
After recanalization, the levels of sE-selectin and sL-selectin were significantly decreased (sE-selectin 54 +/- 15 to 42 +/- 11 ng/ml, sL-selectin 1104 +/- 106 to 891 +/- 59 ng/ml, P < 0.05, respectively).
Negative_regulation (decreased) of sL-selectin
19) Confidence 0.02 Published 1997 Journal Vasc Med Section Abstract Doc Link 9546964 Disease Relevance 0.66 Pain Relevance 0.43
After recanalization, the levels of sE-selectin and sL-selectin were significantly decreased (sE-selectin 54 +/- 15 to 42 +/- 11 ng/ml, sL-selectin 1104 +/- 106 to 891 +/- 59 ng/ml, P < 0.05, respectively).
Negative_regulation (decreased) of sL-selectin
20) Confidence 0.02 Published 1997 Journal Vasc Med Section Abstract Doc Link 9546964 Disease Relevance 0.65 Pain Relevance 0.43

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