INT307794

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.95
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
heart 3
kidney 1
Ace (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 12 88.92 High High
Inflammation 13 86.88 High High
fibrosis 40 82.28 Quite High
imagery 9 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Duchenne Muscular Dystrophy 20 99.34 Very High Very High Very High
Cancer 226 99.32 Very High Very High Very High
Muscular Dystrophy 140 99.18 Very High Very High Very High
Metastasis 240 98.98 Very High Very High Very High
Colon Cancer 246 98.76 Very High Very High Very High
Frailty 75 96.98 Very High Very High Very High
Cardiomyopathy 63 90.68 High High
INFLAMMATION 11 86.88 High High
Hypertension 7 82.48 Quite High
Fibrosis 55 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in the late plateau stages (day 21 onwards) of CRC metastases growth, captopril treatment was associated with a reversion of ACE expression back to the levels seen in untreated tumors at day 21.
Negative_regulation (reversion) of Gene_expression (expression) of ACE associated with cancer, colon cancer and metastasis
1) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 0.91 Pain Relevance 0
The timing of this reduction in ACE expression is of interest as it occurs during the critical exponential growth phase (day 10 to 19).
Negative_regulation (reduction) of Gene_expression (expression) of ACE
2) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.05 Pain Relevance 0
The significant reduction in ACE expression at day 16 following captopril treatment suggests that in addition to the inhibition of ACE activity, captopril also reduces ACE levels, presumably leading to an even greater inhibition of ANG II production.
Negative_regulation (reduction) of Gene_expression (expression) of ACE
3) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.33 Pain Relevance 0
ACE-2 is expressed in the kidney, heart and other organs and is not inhibited by ACE inhibitors [17].
Negative_regulation (inhibited) of Gene_expression (expressed) of ACE in heart
4) Confidence 0.41 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.35 Pain Relevance 0
ACE inhibitors can increase mitochondrial numbers and IGF-I levels thereby helping to counter sarcopenia.102–107 People with the II genotype of the ACE gene who have low serum ACE levels show an increased response to physical endurance.108,109 Therefore, lowering serum ACE levels with ACE inhibitors may have a beneficial effect on physical function.
Negative_regulation (lowering) of Gene_expression (levels) of ACE associated with frailty
5) Confidence 0.26 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2938029 Disease Relevance 0.70 Pain Relevance 0.04
ACE-2 is expressed in the kidney, heart and other organs and is not inhibited by ACE inhibitors [17].
Negative_regulation (inhibited) of in kidney Gene_expression (expressed) of ACE in heart
6) Confidence 0.14 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.35 Pain Relevance 0
An uncontrolled retrospective study showed that echocardiographic parameters, including left ventricular ejection fraction, fractional shortening, and sphericity index, in DMD and BMD patients improved 3 years after administration of either ACE inhibitors alone or the combination of both ACE-inhibitors and ?
Negative_regulation (administration) of Gene_expression (combination) of ACE associated with duchenne muscular dystrophy and muscular dystrophy
7) Confidence 0.14 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 1.26 Pain Relevance 0.15

General Comments

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