INT307797

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ang) extracellular space (Ang) extracellular region (Ang)
RNA binding (Ang) nucleus (Ang) nuclease activity (Ang)
Anatomy Link Frequency
plasma 2
Ang (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 1 89.44 High High
antagonist 5 68.80 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 75 91.24 High High
Colon Cancer 82 84.48 Quite High
Metastasis 80 84.16 Quite High
Chronic Renal Failure 64 77.52 Quite High
Fibrosis 5 64.08 Quite High
Renal Disease 23 52.24 Quite High
Proteinuria 21 50.48 Quite High
Lung Cancer 3 48.76 Quite Low
Death 8 28.12 Quite Low
Targeted Disruption 2 22.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significant reduction in ACE expression at day 16 following captopril treatment suggests that in addition to the inhibition of ACE activity, captopril also reduces ACE levels, presumably leading to an even greater inhibition of ANG II production.
Negative_regulation (inhibition) of Gene_expression (production) of ANG
1) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.06 Pain Relevance 0
Unlike ACE inhibitors, ARBs and other antihypertensive agents that cause an increase in plasma renin activity, aliskiren directly inhibits the catalytic activity of renin, thus reducing plasma renin activity and, in turn, the production of Ang II and aldosterone [63].
Negative_regulation (reducing) of Gene_expression (production) of Ang in plasma
2) Confidence 0.28 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.24 Pain Relevance 0.11

General Comments

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