INT307798

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.73
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Agtrap) endoplasmic reticulum (Agtrap) plasma membrane (Agtrap)
Anatomy Link Frequency
liver 4
Agtrap (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 7 75.36 Quite High
chemokine 4 74.40 Quite High
Inflammation 22 70.32 Quite High
cytokine 14 66.16 Quite High
metalloproteinase 4 41.80 Quite Low
Inflammatory response 6 31.56 Quite Low
ischemia 7 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 164 99.84 Very High Very High Very High
Metastasis 160 99.68 Very High Very High Very High
Cancer 151 98.24 Very High Very High Very High
Lung Cancer 6 97.76 Very High Very High Very High
Atherosclerosis 19 96.64 Very High Very High Very High
Adhesions 7 94.88 High High
Apoptosis 2 89.40 High High
Vasculitis 1 87.48 High High
Cardiovascular Disease 18 83.68 Quite High
Death 10 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in our study we found that AT1R expression was lower in CRC metastases compared to the surrounding liver.
Negative_regulation (lower) of Gene_expression (expression) of AT1R in liver associated with colon cancer and metastasis
1) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.78 Pain Relevance 0
AT1R expression in the liver was reduced by captopril treatment at days 5 (P = 0.0001) and 16 (P = 0.0003) (Figure 2).
Negative_regulation (reduced) of Gene_expression (expression) of AT1R in liver
2) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.82 Pain Relevance 0
inhibits AT1R gene expression at a transcriptional level in VSMCs [37–39].
Negative_regulation (inhibits) of Gene_expression (expression) of AT1R
3) Confidence 0.14 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 1.13 Pain Relevance 0.17

General Comments

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