INT307936

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Context Info
Confidence 0.57
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.92
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcg2) ATPase activity (Abcg2) plasma membrane (Abcg2)
nucleus (Abcg2)
Anatomy Link Frequency
lens 1
CSCs 1
Abcg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 2 89.16 High High
Potency 4 80.80 Quite High
rheumatoid arthritis 1 30.80 Quite Low
cytokine 2 15.92 Low Low
Central nervous system 7 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 105 98.36 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 15 95.12 Very High Very High Very High
Recurrence 9 94.80 High High
Breast Cancer 54 87.44 High High
Fever 3 83.64 Quite High
Colitis 1 82.84 Quite High
Cytomegalovirus Infection 1 81.96 Quite High
Pneumonia 1 81.76 Quite High
Pleural Effusion 18 81.24 Quite High
Lymphocytosis 2 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real-time semiquantitative RT-PCR showed that lens epithelial SP cells express higher levels of ABCG2 than non-SP cells.
Positive_regulation (levels) of ABCG2 in lens
1) Confidence 0.57 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0 Pain Relevance 0.04
These include upregulation of the ABCB1 or ABCG2 drug efflux pumps,58,63,64 downregulation of human organic cation transporter 1 (hOCT1) drug influx transporters,65,66 overexpression of Lyn, a Src-family kinase,67 and other Bcr-Abl-independent mechanisms.
Positive_regulation (upregulation) of ABCG2
2) Confidence 0.23 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.61 Pain Relevance 0.04
One important feature of CSCs is their resistance to the cytotoxicity of varous chemotherapeutic agents because of their relatively high expression levels of multiple drug resistance transporters such as ABCB1 (MDR1/PGP, P-glycoprotein) and ABCG2 (MXR/BCRP) [38].
Positive_regulation (resistance) of MXR in CSCs
3) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 1.31 Pain Relevance 0

General Comments

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