INT308130

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.49
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1, F2) peptidase activity (F2) extracellular space (F2)
transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
blood 1
platelet 1
F13A1 (Homo sapiens)
F2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 100 91.68 High High
Adhesions 8 6.56 Low Low
Body Weight 8 5.00 Very Low Very Low Very Low
Thrombosis Related Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrate that OG488-active site-labeled thrombin bound ubiquitously to fibrin-platelet structures, as evidenced by a fluorescence area coverage of 35.0±4.0% and a low overlap (Rr?
fibrin Binding (bound) of thrombin in platelet
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861630 Disease Relevance 0 Pain Relevance 0
Thrombin bound to this high affinity site on fibrin(ogen) has been shown to be enzymatically active and protected from inhibition by the heparin-antithrombin complex [33], [38].
fibrin Binding (bound) of Thrombin
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861630 Disease Relevance 0.18 Pain Relevance 0
Thrombin is a critical player in blood coagulation and is known to bind to the platelet surface and to fibrin(ogen) [13], [29], [30], [31], [32]; however, where thrombin is localized during clot formation is largely unknown.
fibrin Binding (bind) of Thrombin in blood
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861630 Disease Relevance 0.16 Pain Relevance 0
Thrombin interacts with fibrin(ogen) though multiple low and high affinity binding sites [33], [34].
fibrin Binding (interacts) of Thrombin
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861630 Disease Relevance 0.14 Pain Relevance 0

General Comments

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