INT308149

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.77
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (Slc22a5) mitochondrion organization (Slc22a5)
Anatomy Link Frequency
plasma 3
small intestine 1
Slc22a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Crohn's disease 5 99.08 Very High Very High Very High
Central nervous system 5 73.84 Quite High
Pain 25 8.00 Low Low
Inflammation 25 5.00 Very Low Very Low Very Low
Bioavailability 25 5.00 Very Low Very Low Very Low
ischemia 20 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
diabetic neuropathy 20 5.00 Very Low Very Low Very Low
cytokine 15 5.00 Very Low Very Low Very Low
Neuropathic pain 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 110 99.08 Very High Very High Very High
Shock 10 98.16 Very High Very High Very High
Weight Gain 5 95.64 Very High Very High Very High
Dementia 20 81.28 Quite High
Muscle Disease 15 78.76 Quite High
Hypoglycemia 5 76.72 Quite High
Encephalopathy 35 75.28 Quite High
Coronary Heart Disease 30 72.88 Quite High
Hepatic Encephalopathy 45 62.40 Quite High
Metabolic Disorder 5 59.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since there is increased OCTN2 expression in the small intestine in response to oxidized fat, and OCTN2 binds not only carnitine but various drugs, it is suggested by the authors that OCTN2 might be harnessed to improve absorption of various drugs [112].
Gene_expression (expression) of OCTN2 in small intestine
1) Confidence 0.63 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2861661 Disease Relevance 0.10 Pain Relevance 0
Elevated plasma membrane OCTN2 carnitine transporter expression was observed in vegetarians compensating for lower carnitine levels obtained from the diet.
Gene_expression (expression) of OCTN2 carnitine transporter in plasma
2) Confidence 0.63 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2861661 Disease Relevance 0.34 Pain Relevance 0
Carnitine transporter mutations in Crohn's disease consists of missense mutation(s) in the gene coding plasma membrane transporter OCTN1 (SLC22A4) and/or mutation(s) in the promoter of the gene encoding OCTN2 (SLC22A5) [14,35].
Gene_expression (coding) of SLC22A5 in plasma associated with crohn's disease and disease
3) Confidence 0.55 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2861661 Disease Relevance 0.79 Pain Relevance 0.09
Carnitine transporter mutations in Crohn's disease consists of missense mutation(s) in the gene coding plasma membrane transporter OCTN1 (SLC22A4) and/or mutation(s) in the promoter of the gene encoding OCTN2 (SLC22A5) [14,35].
Gene_expression (coding) of OCTN2 in plasma associated with crohn's disease and disease
4) Confidence 0.55 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2861661 Disease Relevance 0.78 Pain Relevance 0.09
Manifestation of these mutations results in disruption of a heat shock binding element decreasing the transport function (OCTN1), and reduced expression (through OCTN2 mutation) which both result in carnitine deficiency [14].
Gene_expression (mutation) of OCTN2 associated with shock
5) Confidence 0.55 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2861661 Disease Relevance 0.77 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox