INT30815

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1983
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.21
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCY1) small molecule metabolic process (ADCY1) plasma membrane (ADCY1)
nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)
Anatomy Link Frequency
granulosa cells 1
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 11 98.96 Very High Very High Very High
opioid receptor 7 98.80 Very High Very High Very High
Morphine 6 98.72 Very High Very High Very High
antagonist 15 96.16 Very High Very High Very High
agonist 67 95.90 Very High Very High Very High
Serotonin 3 95.76 Very High Very High Very High
adenocard 71 93.20 High High
Neurotransmitter 5 92.80 High High
Central nervous system 2 91.52 High High
Potency 27 90.48 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 95.60 Very High Very High Very High
Drug Dependence 1 53.96 Quite High
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Cystic Fibrosis 3 5.00 Very Low Very Low Very Low
Myocardial Infarction 3 5.00 Very Low Very Low Very Low
Infarction 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Characterization of adenylyl cyclases in cultured human granulosa cells.
adenylyl cyclase Binding (Characterization) of in granulosa cells
1) Confidence 0.36 Published 2001 Journal Reproduction Section Title Doc Link 11226046 Disease Relevance 0 Pain Relevance 0.04
DPDPE-induced adenylyl cyclase supersensitization was not associated with an increase in the phosphorylation of CREBs.
adenylyl cyclase Binding (associated) of
2) Confidence 0.32 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737627 Disease Relevance 0.11 Pain Relevance 0.76
An enhancing action of GTP on the inhibitory influences of morphine suggests that its actions are mediated at least in part, via a coupling of the receptor to adenyl cyclase in the outer membrane.
cyclase Binding (coupling) of associated with morphine
3) Confidence 0.27 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 2874808 Disease Relevance 0 Pain Relevance 0.58
When expressed in cultured cells, it displayed the pharmacological profile and negative coupling with adenylyl cyclase characteristic of a 5-HT1B receptor subtype.
cyclase Neg (negative) Binding (coupling) of
4) Confidence 0.12 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 8302276 Disease Relevance 0 Pain Relevance 0.28
Furthermore, the functional opioid-like activity of the anti-opioid receptor IgG was demonstrated by their ability to inhibit adenylate cyclase activity by a Gi/o-protein-mediated mechanism as indicated by abrogation of the effect by either opioid antagonist or pertussis toxin.
cyclase Binding (activity) of associated with bordatella infection, antagonist, opioid receptor and opioid
5) Confidence 0.02 Published 1999 Journal Eur. J. Immunol. Section Abstract Doc Link 10092104 Disease Relevance 0.10 Pain Relevance 0.91
CGS21680 has, in fact, been considered one of the most potent A2A AR agonist and the ligand of choice to distinguish A2A- and A2B AR-mediated effects (Ki values from binding assays for hA1, hA2A and hA3 AR subtypes of 298, 27 and 67 nM respectively; EC50 value from stimulation of adenylyl cyclase activity through A2B AR of 88.8 ?
adenylyl cyclase Binding (activity) of associated with agonist
6) Confidence 0.02 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0 Pain Relevance 0.09
Adenylate cyclase response to prostaglandins and their interaction with the adrenergic system.
cyclase Binding (interaction) of
7) Confidence 0.00 Published 1983 Journal Life Sci. Section Title Doc Link 6339855 Disease Relevance 0 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox