INT30817

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Context Info
Confidence 0.76
First Reported 1986
Last Reported 2011
Negated 1
Speculated 8
Reported most in Abstract
Documents 142
Total Number 150
Disease Relevance 33.56
Pain Relevance 38.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
neurons 24
dopamine neurons 8
neuronal 7
striatum 6
brain 4
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 4540 100.00 Very High Very High Very High
Substantia nigra 571 100.00 Very High Very High Very High
Ventral tegmentum 296 100.00 Very High Very High Very High
adenocard 163 100.00 Very High Very High Very High
Glutamate 124 100.00 Very High Very High Very High
Enkephalin 47 100.00 Very High Very High Very High
Neuropeptide 43 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
midbrain 549 99.88 Very High Very High Very High
Calcitonin gene-related peptide 36 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 2275 99.66 Very High Very High Very High
Targeted Disruption 651 99.52 Very High Very High Very High
Hypertrophy 21 99.50 Very High Very High Very High
INFLAMMATION 739 99.48 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 58 99.44 Very High Very High Very High
Aging 198 98.84 Very High Very High Very High
Disease 1162 98.76 Very High Very High Very High
Death 309 98.76 Very High Very High Very High
Sprains And Strains 99 98.72 Very High Very High Very High
Drug Induced Neurotoxicity 194 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study suggests that Brn-3a may normally suppress TH expression in many small DRG neurons but activate TH expression in large DRG neurons.
Gene_expression (expression) of TH in DRG
1) Confidence 0.76 Published 2005 Journal Brain Res. Section Abstract Doc Link 15725417 Disease Relevance 0.33 Pain Relevance 0.04
The present study suggests that Brn-3a may normally suppress TH expression in many small DRG neurons but activate TH expression in large DRG neurons.
Gene_expression (expression) of TH in DRG
2) Confidence 0.76 Published 2005 Journal Brain Res. Section Abstract Doc Link 15725417 Disease Relevance 0.33 Pain Relevance 0.04
Chronic opiate exposure induces numerous neurochemical adaptations in the noradrenergic system, including upregulation of the cAMP-signaling pathway and increased expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis.
Gene_expression (expression) of TH associated with catecholamine and opiate
3) Confidence 0.76 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12019333 Disease Relevance 0.09 Pain Relevance 0.60
Here we report that noradrenergic locus ceruleus (LC) neurons of mice with a conditional deletion of BDNF in postnatal brain respond to chronic morphine treatment with a paradoxical downregulation of cAMP-mediated excitation and lack of dynamic regulation of TH expression.
Gene_expression (expression) of TH in neurons associated with locus ceruleus and morphine
4) Confidence 0.76 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12019333 Disease Relevance 0.18 Pain Relevance 0.97
Chronic opiate exposure induces numerous neurochemical adaptations in the noradrenergic system, including upregulation of the cAMP-signaling pathway and increased expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis.
Gene_expression (expression) of tyrosine hydroxylase associated with catecholamine and opiate
5) Confidence 0.76 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12019333 Disease Relevance 0.09 Pain Relevance 0.60
In LC, beta-gal expression was induced predominantly in tyrosine hydroxylase-expressing cells, whereas in the VTA and DRN the majority of cells expressing beta-gal were nonmonoaminergic.
Gene_expression (expressing) of tyrosine hydroxylase in DRN associated with ventral tegmentum and locus ceruleus
6) Confidence 0.75 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.20 Pain Relevance 1.26
Furthermore, in the previous study, subchronic antipsychotic medication reduced TH immunostaining in the striatum and caused shrinkage of dopaminergic cell bodies in substantia nigra.33 Lerner et al.34 reported changes of TH Vmax (maximal transport capacity) after chronic haloperidol administration and suggested that TH protein expression is elevated by long-term haloperidol treatment.
Gene_expression (expression) of TH in substantia nigra associated with substantia nigra
7) Confidence 0.74 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796069 Disease Relevance 0.72 Pain Relevance 0.33
These results suggest that chronic morphine upregulates TH expression via transcriptional mechanisms in the locus coeruleus but by post-transcriptional mechanisms in the ventral tegmental area.
Gene_expression (expression) of TH in locus coeruleus associated with ventral tegmentum, locus ceruleus and morphine
8) Confidence 0.67 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822754 Disease Relevance 0.15 Pain Relevance 0.78
The levels of dopamine transporter (DAT), tyrosine hydroxylase (TH), major biogenic amines including DA, 5-hydroxytryptamine (5-HT), and their metabolites were examined.
Spec (examined) Gene_expression (levels) of TH associated with dopamine
9) Confidence 0.67 Published 2001 Journal Synapse Section Abstract Doc Link 11169780 Disease Relevance 0.37 Pain Relevance 0.38
The levels of dopamine transporter (DAT), tyrosine hydroxylase (TH), major biogenic amines including DA, 5-hydroxytryptamine (5-HT), and their metabolites were examined.
Spec (examined) Gene_expression (levels) of tyrosine hydroxylase associated with dopamine
10) Confidence 0.67 Published 2001 Journal Synapse Section Abstract Doc Link 11169780 Disease Relevance 0.36 Pain Relevance 0.38
RT97, CGRP, and TH immunoreactive fibers were present in parenchyma of the head, body and tail of the pancreas with the relative density of both RT97 and CGRP expressing fibers being head>body>tail, whereas for TH, a relatively even distribution was observed.
Gene_expression (present) of TH in head associated with calcitonin gene-related peptide
11) Confidence 0.65 Published 2006 Journal Neuroscience Section Abstract Doc Link 16388907 Disease Relevance 0.36 Pain Relevance 0.49
Increased expression of tyrosine hydroxylase mRNA was found in the ventral tegmental area and substantia nigra pars compacta of chronic caffeine-treated (20-80 mg/kg × 9 days) rats [23].
Gene_expression (expression) of tyrosine hydroxylase mRNA in ventral associated with ventral tegmentum and substantia nigra
12) Confidence 0.64 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0.13 Pain Relevance 0.52
Although there is extensive evidence for TH-ir neurones in the lesioned rodent striatum, there are few details regarding the molecular phenotype of these neurones, regulation of their TH expression after l-3,4-dihydroxyphenylalanine (L-DOPA) treatment and their function.
Gene_expression (expression) of TH in striatum
13) Confidence 0.61 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279311 Disease Relevance 0.09 Pain Relevance 0.08
Levels of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, are known to be upregulated in specific brain regions by chronic administration of drugs of abuse.
Gene_expression (Levels) of tyrosine hydroxylase in brain associated with catecholamine
14) Confidence 0.60 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822754 Disease Relevance 0.07 Pain Relevance 0.37
Chronic morphine administration increases TH levels in the locus coeruleus and ventral tegmental area, whereas chronic cocaine administration increases TH levels in the ventral tegmental area only.
Gene_expression (levels) of TH in ventral associated with ventral tegmentum, locus ceruleus, cocaine and morphine
15) Confidence 0.60 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822754 Disease Relevance 0.13 Pain Relevance 0.52
Chronic morphine administration increases TH levels in the locus coeruleus and ventral tegmental area, whereas chronic cocaine administration increases TH levels in the ventral tegmental area only.
Gene_expression (levels) of TH in ventral associated with ventral tegmentum, locus ceruleus, cocaine and morphine
16) Confidence 0.60 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822754 Disease Relevance 0.14 Pain Relevance 0.53
Levels of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, are known to be upregulated in specific brain regions by chronic administration of drugs of abuse.
Gene_expression (Levels) of TH in brain associated with catecholamine
17) Confidence 0.60 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822754 Disease Relevance 0.07 Pain Relevance 0.37
The populations of tyrosine hydroxylase (TH)-expressing hypothalamic cells are sexually dimorphic in rats and mice [20,21].
Gene_expression (expressing) of tyrosine hydroxylase
18) Confidence 0.57 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0.09 Pain Relevance 0
The AVPv of the hypothalamus is sexually dimorphic and the neurons that express tyrosine hydroxylase (TH) are more abundant in that of the female [31].
Gene_expression (express) of tyrosine hydroxylase in neurons
19) Confidence 0.57 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0.13 Pain Relevance 0
Reduced tyrosine hydroxylase expression in the FucM mutant
Gene_expression (expression) of tyrosine hydroxylase
20) Confidence 0.57 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0.09 Pain Relevance 0

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