INT308172

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.68
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1)
Anatomy Link Frequency
RVM 2
Rvm (Mus musculus)
GRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 5 100.00 Very High Very High Very High
Rostral ventromedial medulla 5 100.00 Very High Very High Very High
Hyperalgesia 7 99.04 Very High Very High Very High
antagonist 2 97.32 Very High Very High Very High
Eae 19 90.96 High High
Neuropathic pain 57 86.80 High High
Pain 10 85.92 High High
Central nervous system 5 76.96 Quite High
analgesia 1 71.76 Quite High
allodynia 13 62.28 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 12 99.04 Very High Very High Very High
Injury 23 90.96 High High
Neuropathic Pain 74 86.80 High High
Pain 15 85.92 High High
Cognitive Disorder 1 66.64 Quite High
Inflammatory Pain 2 55.28 Quite High
Hypertrophy 1 47.32 Quite Low
INFLAMMATION 19 37.00 Quite Low
Nociception 8 33.20 Quite Low
Nervous System Injury 15 30.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
into RVM increases NR1 phosphorylation of NMDA receptors and produces hyperalgesia, which is reversed by an NMDA antagonist.
RVM Positive_regulation (increases) of Phosphorylation (phosphorylation) of NMDA in RVM associated with hyperalgesia, antagonist, nmda receptor and rostral ventromedial medulla
1) Confidence 0.50 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.68 Pain Relevance 1.14

General Comments

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