INT308173

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.64
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DRG1, Tnfrsf1b) cell death (Tnfrsf1b) transcription factor binding (DRG1)
cytoplasm (DRG1)
DRG1 (Homo sapiens)
Tnfrsf1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 26 96.20 Very High Very High Very High
Hyperalgesia 14 95.64 Very High Very High Very High
Eae 38 94.60 High High
Lasting pain 10 75.96 Quite High
Spinal cord 10 50.92 Quite High
Neuropathic pain 114 50.00 Quite Low
Pain 20 45.36 Quite Low
intrathecal 6 29.28 Quite Low
Etanercept 8 26.88 Quite Low
cytokine 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 148 96.20 Very High Very High Very High
Herpes Simplex Virus 4 95.76 Very High Very High Very High
Hyperalgesia 24 95.64 Very High Very High Very High
Injury 46 94.60 High High
Pain 30 75.96 Quite High
Nervous System Injury 30 64.88 Quite High
Cold Sores 4 63.32 Quite High
Frailty 4 51.20 Quite High
INFLAMMATION 38 5.00 Very Low Very Low Very Low
Cancer 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, over-expressed p55 sTNFR (sTNFR2) binds to the mTNF of DRG and down-regulates overall production of TNF by reverse signaling, significantly reducing the allodynia and hyperalgesia responses to CCI [170,171].
DRG Binding (binds) of sTNFR associated with hyperalgesia, allodynia and eae
1) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.82 Pain Relevance 0.55
As a result, over-expressed p55 sTNFR (sTNFR2) binds to the mTNF of DRG and down-regulates overall production of TNF by reverse signaling, significantly reducing the allodynia and hyperalgesia responses to CCI [170,171].
DRG Binding (binds) of sTNFR2 associated with hyperalgesia, allodynia and eae
2) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.82 Pain Relevance 0.55

General Comments

This test has worked.

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